Program Book - Confex

5:15 pm
2532. Selection of Patients with Ankylosing Spondylitis for TNF-
Inhibitor Therapy: Comparing Responses in Patients Selected
by BASDAI & ASDAS
Karen Minde Fagerli 1 , Elisabeth Lie 2 , D.M.F.M. van der Heijde 3 ,
Marte S. Heiberg 1 , Synnøve Kalstad 4 , Erik Rødevand 5 , Cecillie
Kaufmann 6 , Knut Mikkelsen 7 and Tore K. Kvien 2 , 1 Diakonhjemmet
hospital, Oslo, Norway, 2 Diakonhjemmet Hospital, Oslo, Norway,
3
Leiden University Medical Center, Leiden, Netherlands,
4
University Hospital in Northern Norway, Tromsø, Norway,
5
St. Olavs Hospital, Trondheim, Norway, 6 Vestre Viken,
Drammen, Norway, 7 Lillehammer Hosp for Rheumatic Diseases,
Lillehammer, Norway
4:45 pm
2536. Anti-Fibrotic Effects of Microrna-145 in Systemic Sclerosis
via a Multi-Step Regulation of TGF-Beta/CTGF Signaling
Serena Vettori 1 , Matthias Brock 1 , Naoki Iwamoto 1 , Britta
Maurer 1 , Astrid Jungel 1 , Renate E. Gay 1 , Maurizio Calcagni 2 ,
Gabriele Valentini 3 , Jorg HW Distler 4 , Steffen Gay 1 and Oliver
Distler 1 , 1 Center of Experimental Rheumatology, University
Hospital Zurich, Zurich, Switzerland, 2 Division of Plastic
Surgery and Hand Surgery, Zurich University Hospital, Zurich,
Switzerland, 3 Rheumatology Unit, Second University of Napoli,
Napoli, Italy, 4 Department of Internal Medicine 3 and Institute
for Clinical Immunology, University of Erlangen-Nuremberg,
Erlangen, Germany
TUESDAY
November 8, 2011
5:30 pm
2533. Obesity and the Risk of Psoriatic Arthritis in the General
Population
Yanyan Zhu 1 , Hyon K. Choi 1 , Yuqing Zhang 1 , Lindsay Wall-Burns 2 ,
Alexis Ogdie 3 , Joel Gelfand 4 and Thorvardur Love 5 , 1 Boston
University School of Medicine, Boston, MA, 2 Arthritis Research
Centre of Canada, Vancouver, BC, 3 University of Pennsylvania,
Philadelphia, PA, 4 University of Pennsylvania., Philadelphia, PA,
5
Landspitali University Hospital, Reykjavík, Iceland
5:45 pm
2534. Frequency and Duration of Drug-Free Remission After
One Year of Treatment with Etanercept Vs. Sulfasalazine in
Early Axial Spondyloarthritis – 2 Year Data of the ESTHER Trial
In-Ho Song 1 , Kay-Geert Hermann 2 , Hildrun Haibel 1 , Christian
Althoff 2 , Denis Poddubnyy 1 , Joachim Listing 3 , Anja Weiß 3 , Bruce
Freundlich 4 , Martin Rudwaleit 5 and Joachim Sieper 1 , 1 Charité
Medical University, Campus Benjamin Franklin, Berlin, Germany,
2
Charite Medical School, Berlin, Germany, 3 German Rheumatism
Research Centre, Berlin, Germany, 4 University of Pennsylvania,
Philadelphia, PA, 5 Ev. Krankenhaus Hagen-Haspe, Hagen,
Germany
W183c
Systemic Sclerosis Fibrosing Syndromes and Raynaud’s
– Pathogenesis, Animal Models and Genetics I
Moderators: Marco Matucci-Cerinic; University Florence;
Firenze, Jordan
Robert A. Lafyatis, MD; Arthritis Center, Boston University School
of Medicine; Boston, MA
4:30 pm
2535. Transforming Growth Factor Beta Mediated Activation
of Canonical Wnt Signaling Is Crucial for the Development of
Fibrosis In Systemic Sclerosis
Alfiya Akhmetshina 1 , Katrin Palumbo 2 , Christina Bergmann 2 ,
Paulius Venalis 2 , Clara Dees 2 , Pawel Zerr 2 , Angelika Horn 2 ,
Christian Beyer 3 , Jochen Zwerina 2 , Ormond A. MacDougald 4 ,
Oliver Distler 5 , Georg Schett 2 and Jorg HW Distler 2 , 1 Department
of Internal Medicine III and Institute for Clinical Immunology,
University of Erlangen-Nuremberg, Erlangen, Germany,
2
Department of Internal Medicine 3 and Institute for Clinical
Immunology, University of Erlangen-Nuremberg, Erlangen,
Germany, 3 University of Erlangen-Nuremberg, Erlangen,
Germany, 4 Department of Pediatrics, University of Erlangen-
Nuremberg, Erlangen, Germany, 5 University Hospital Zurich,
Zurich, Switzerland
5:00 pm
2537. TLR4 Activation Enhances Fibrotic Responses Induced by
TGF-ß: A Mechanism for Maintaining and Amplifying Fibrosis in
Scleroderma
Swati Bhattacharyya 1 , Kathleen Kelly 2 , Denisa S. Melichian 2 ,
Kohtaro Ooka 3 , Carol A. Feghali-Bostwick 4 , Robert A. Lafyatis 5 ,
Timothy RD Radstake 6 and John Varga 1 , 1 Northwestern Univ
Med School, Chicago, IL, 2 Northwestern University, Chicago, IL,
3
Northwestern University, 4 University of Pittsburgh, Pittsburgh,
PA, 5 E5 Arthritis Ctr-BUSM, Boston, MA, 6 Radboud University
Nijmegen Medical Centre, Nijmegen, Netherlands
5:15 pm
2538. Tribbles Homolog 3 mediates Transforming Growth
Factor beta driven Dermal Fibrosis In Systemic Sclerosis
Michal Tomcik 1 , Katrin Palumbo 2 , Jérôme Avouac 3 , Angelika
Horn 2 , Aisa Khodzhigorova 2 , Pawel Zerr 2 , Clara Dees 2 , Alfiya
Akhmetshina 4 , Christian Beyer 5 , Radim Becvar 1 , Ladislav Senolt6,
Oliver Distler 7 , Georg Schett 2 and Jorg HW Distler 2 , 1 Institute
of Rheumatology, Department of Clinical and Experimental
Rheumatology, 1st Faculty of Medicine, Charles University,
Prague, Czech Republic, 2 Department of Internal Medicine 3
and Institute for Clinical Immunology, University of Erlangen-
Nuremberg, Erlangen, Germany, 3 Paris Descartes University,
Rheumatology A department, Cochin Hospital, Paris, France,
4
Department of Internal Medicine III and Institute for Clinical
Immunology, University of Erlangen-Nuremberg, Erlangen,
Germany, 5 University of Erlangen-Nuremberg, Erlangen,
Germany, 6 Institute of Rheumatology, 1st Faculty of Medicine,
Charles University, Prague, Czech Republic, 7 University Hospital
Zurich, Zurich, Switzerland
5:30 pm
2539. Inhibition of Glycogen Synthase Kinase 3β Induces
Dermal Fibrosis by Activation of the Canonical Wnt Pathway
Christina Bergmann 1 , Alfiya Akhmetshina 2 , Clara Dees 1 , Katrin
Palumbo 1 , Pawel Zerr 1 , Christian Beyer 3 , Jochen Zwerina 1 , Oliver
Distler 4 , Georg Schett 1 and Jorg HW Distler 1 , 1 Department of
Internal Medicine 3 and Institute for Clinical Immunology,
University of Erlangen-Nuremberg, Erlangen, Germany,
2
Department of Internal Medicine III and Institute for Clinical
Immunology, University of Erlangen-Nuremberg, Erlangen,
Germany, 3 University of Erlangen-Nuremberg, Erlangen,
Germany, 4 University Hospital Zurich, Zurich, Switzerland
112
2011 Program Book