Program Book - Confex

ACR/ARHP Poster Session C
Tampere School of Medicine, Tampere University Hospital,
and Coxa Hospital for Joint Replacement, Tampere, Finland
1777. Mast Cell-Restricted, Tetramer-Forming Tryptases Are
Novel Mediators of Articular Cartilage Aggrecanolysis
by Activating Matrix Metalloprotease Zymogens. Natalia
Magarinos 1 , Katherine J. Bryant 1 , Amanda J. Fosang 2 , Richard
L. Stevens 3 and H. Patrick McNeil 1 , 1 University of New
South Wales, Sydney, Australia, 2 University of Melbourne,
Melbourne, Australia, 3 Brigham & Women’s Hospital and
Harvard Medical School, Boston, MA
1778. Calcium Mineral Deposition In the Cultures of Fibroblast-
Like Synoviocytes. Yubo Sun, David Mauerhan, Atiya
Franklin, Andrew Sun, Natalia Zinchenko, H. Norton, Edward
Hanley Jr. and Helen Gruber, Carolinas Medical Center,
Charlotte, NC
1779. Infliximab Does Reverse Cytokine - Mediated Anti-
Apoptotic Effects In CD14+/CD11b+ Circulating Monocytes
– Implications for Osteoclastogenesis. Michael Seitz, Daniel
Aeberli, Richard K. Kamgang, Willy Hofstetter, Deepak Balani
and Peter M. Villiger, University Hospital, Bern, Switzerland
1780. New Alginate-Chitosan Hydrogel Beads with Anti-
Inflammatory and Anabolic Effects on Human
Chondrocytes. Frédéric Oprenyeszk 1 , Christelle Sanchez 1 ,
Jean-Emile Dubuc 2 , Véronique Maquet 3 and Yves Henrotin 4 ,
1
University of Liège, Liège, Belgium, 2 Clinical University Saint
Luc, Bruxelles, Belgium, 3 KitoZyme SA, Herstal, Belgium,
4
Univ of Liege/Pathology Inst, Liege, Belgium
1781. Activation of Adenosine A2A Receptors Prevents Wear
Particle-Induced Osteolysis. Aranzazu Mediero 1 , Sally
Frenkel 2 , Tuere Wilder 1 and Bruce N. Cronstein 3 , 1 NYU School
of Medicine, New York, NY, 2 Hospital for Joint Disease, New
York, NY, 3 New York Univ Medical Center, New York, NY
1782. Heme Oxygenase-1 Lentiviral Transduction of Human
Osteoarthritic Osteoblasts Down-Regulates Inflammatory,
Degradative and Senescence Markers. Maria Isabel
Guillen 1 , Victoria Clerigues 1 , Miguel Angel Castejon 2 ,
Francisco Gomar 3 and Maria Jose Alcaraz 1 , 1 University of
Valencia, Burjasot, Valencia, Spain, 2 La Ribera Hospital,
Alzira, Valencia, Spain, 3 University of Valencia and University
Hospital, Valencia, Spain
1783. Human End-Stage Osteoarthritic Cartilage is Responsive
to Transforming Growth Factor Beta and Contains a
Population of Cells That Expresses SMAD2/3P and
SMAD1/5/8P. Arjan P. M. van Caam, Esmeralda N. Blaney
Davidson, Elly L. Vitters, Wim B. van den Berg and Peter
M. van der Kraan, Radboud University Nijmegen Medical
Centre, Nijmegen, Netherlands
1784. A Single Injection of Adipose-Derived Stem cells Protects
Against Cartilage Damage and Lowers Synovial Activation
in Experimental Osteoarthritis. Menno C. ter Huurne 1 , Peter
L.E.M. van Lent 1 , Arjen B. Blom 1 , Roxane Blattes 2 , Yannick
Jeanson 2 , Louis Casteilla 2 , Christian Jorgensen 3 and Wim
B. van den Berg 1 , 1 Radboud University Nijmegen Medical
Centre, Nijmegen, Netherlands, 2 INSERM U103 1 , Toulouse,
France, 3 Hospital Lapeyronie, Montpellier, France
1785. Chondrocytes in a Subset of Osteo-Arthritic Patients with
Reduced NuclearFactorkappaB-p65 Levels Are Vulnerable
to Apoptosis Induced by Tumor Necrosis Factor Alpha,
Which Could Be Released by the Synovium. Onno J. Arntz,
Eline A. Vermeij, Esmeralda N. Blaney Davidson, Shahla
Abdollahi-Roodsaz, Miranda B. Bennink, Peter M. van der
Kraan, Wim B. van den Berg and Fons Van De Loo, Radboud
University Nijmegen Medical Centre, Nijmegen, Netherlands
1786. Adipokines Leptin and Adiponectin Correlate with Matrix
Metalloproteinases and Interleukin-6 in Synovial Fluid
From Osteoarthritis Patients and Enhance Their Production
in Osteoarthritic Cartilage Ex Vivo. Katriina Vuolteenaho 1 ,
Anna Koskinen 1 , Sami Juslin 1 , Riina Nieminen 1 , Teemu
Moilanen 2 and Eeva Moilanen 1 , 1 The Immunopharmacology
Research Group, University of Tampere School of Medicine,
and Tampere University Hospital, Tampere, Finland, 2 Coxa
Hospital for Joint Replacement, Tampere, Finland
1787. Adenosine A1 Receptor Blockade Inhibits Osteoclast
Formation of Mouse Bone Marrow Cells by
Downregulation RANKL Signaling. Wenjie He 1 and Bruce
N. Cronstein 2 , 1 NYU, New York, NY, 2 New York Univ Medical
Center, New York, NY
1788. MAPK-Activated Protein Kinase-2 (MK2) Regulates Bone
Homeostasis. Tobias Braun 1 , Johannes Lepper 1 , Gisela Ruiz
Heiland 1 , Georg Schett 1 and Jochen Zwerina 2 , 1 University
of Erlangen-Nuremberg, Erlangen, Germany, 2 Hanusch
Hospital, Vienna, Austria
1789. Human MSCs Ameliorate Bone Erosion in TNF-Alpha
Transgenic Mice. Joy M. Whitbred 1 , Robert M. Lowe 2 ,
Donald P. Lennon 3 , Joseph Molter 4 , Chris A. Flask 4 , Tracey
L. Bonfield 2 , Arnold I. Caplan 3 and Nora G. Singer 1 , 1 Division
of Rheumatology, MetroHealth Medical Center, Case
Western Reserve University, Cleveland, OH, 2 Department of
Pediatrics, Case Western Reserve University, Cleveland, OH,
3
Skeletal Research Center, Case Western Reserve University,
Cleveland, OH, 4 Department of Radiology, Case Western
Reserve University, Cleveland, OH
1790. The Role of Mir-29 in the Chondrogenic Differentiation
of Mesenchymal Stem Cells. D. Guerit 1 , D. Philipot 2 ,
P. Chuchana 1 , JM Brondello 2 , Christian Jorgensen 3 and
Daniele Noel 2 , 1 INSERM U844, Montpellier, France, 2 UM 1 ,
Montpellier, France, 3 CHU Lapeyronie, Montpellier, France
1791. Activation of AMP-Activated Protein Kinase (AMPK)
Alleviates Endoplasmic Reticulum (ER) Stress and
Inhibits Catabolic Responses to Biomechanical Injury in
Chondrocytes. Freyr Petursson 1 , Xianling Zhao 1 , Robert
Terkeltaub 2 and Ru L. Bryan 1 , 1 UCSD/VAMC, San Diego, CA,
2
VA Medical Ctr, San Diego, CA
1792. Apolipoprotein E and Undercarboxylated Osteocalcin Are
Associated with Bone Fragility but Not with Bone Mineral
Density in Osteoarthritis Patients. Ana M. Rodrigues 1 ,
254
2011 Program Book