Program Book - Confex

SUNDAY
November 6, 2011
48
Musculoskeletal Biomedical Research Unit, University of Oxford,
Oxford, UK, Oxford, United Kingdom, 4 Southampton General
Hospital, Southampton, United Kingdom, 5 Center for Outcomes
Research, UMass Medical School, Worcester, MA, 6 Hospital del
Mar-IMIM, Universitat Autònoma de Barcelona, Barcelona; and
RETICEF, ISCIII Madrid; Spain, Barcelona, Spain
35:45 pm
830. Association of Candidate Single Nucleotide
Polymorphisms with Radiographic Knee Osteoarthritis in
African-Americans: Data From the Genetic Components of
Knee Osteoarthritis Study
Rebecca Jackson 1 , Changwan (Larry) Lu 2 , Laura Yerges-
Armstrong 2 , David Duggen 3 , Marc Hochberg 2 , Braxton Mitchell 2
and OAI Investigators 4 , 1 Ohio State University, Columbus, OH,
2
University of Maryland School of Medicine, Baltimore, MD,
3
TGen, Pheonix, AZ, 4 San Francisco
W475a
Rheumatoid Arthritis – Animal Models I
Moderators: David S. Bradley, MD; University of North Dakota
School of Medicine; Grand Forks, ND
Paul H. Wooley, PhD; Via Christi Regional Medical Center;
Wichita, KS
4:30 pm
831. Nanoparticle Encapsulated STAT1 siRNAs Induce
Regression of Established Collagen Arthritis In Mice
Robert I. Scheinman, Ruchit Trivedi and Uday Kompella,
University of Colorado Denver, Aurora, CO
4:45 pm
832. Identification of Microrna-221, -222 and -323-3p
Association with Rheumatoid Arthritis Via Predictions Using
the Human TNF Transgenic Mouse Model
Ioannis Pandis 1 , Caroline Ospelt 2 , Niki Karagianni 3 , Maria
C. Denis 4 , Martin Reczko 5 , Artemis Hatzigeorgiou 5 , Jiannis
Ragoussis 6 , Steffen Gay 2 and George Kollias 1 , 1 Institute of
Immunology, Biomedical Sciences Research Center ‘Alexander
Fleming’, Vari, Greece, 2 Center of Experimental Rheumatology,
University Hospital Zurich, Zurich, Switzerland, 3 Institute of
Immunology, Biomedical Sciences Research Center ‘Alexander
Fleming’ and Biomedcode Hellas SA, Vari, Greece, 4 BiomedCode
Hellas SA, Vari, Greece, 5 Institute of Molecular Oncology,
Biomedical Sciences Research Center ‘Alexander Fleming’, Vari,
Greece, 6 Institute of Molecular Biology & Genetics, Biomedical
Sciences Research Center ‘Alexander Fleming’ and Wellcome
Trust Centre for Human Genetics, University of Oxford, Oxford,
United Kingdom
5:00 pm
833. Why p38 Inhibitors Are Ineffective in Rheumatoid Arthritis
(RA): Increased Pro-Inflammatory Macrophage Function
Monica Guma, Deepa Hammaker, Meghan Edgar, Katharyn
Topolewski, Mary Corr and Gary S. Firestein, UCSD School of
Medicine, La Jolla, CA
5:15 pm
834. Superior Efficacy of Ozoralizumab, An Anti-Human TNF
Nanobody in a Transgenic Mouse Model of Polyarthritis
Martin Hegen 1 , Els Beirnaert 2 , Guy Hermans 2 , Peter
Casteels 2 , Marina Shen 1 , Julie Lee 1 , Lori Fitz 1 , Nilufer Seth 1 ,
Yulia Vugmeyster 1 , Christopher Wrocklage 1 , Kyri Dunussi-
2011 Program Book
Joannopoulos 1 , Cheryl L. Nickerson-Nutter1 and Mary Collins 1 ,
1
Pfizer, Cambridge, MA, 2 Ablynx nv, Zwijnaarde, Belgium
5:30 pm
835. CXCL5 An Important IL-17 Mediated Proangiogenic Factor
in Rheumatoid Arthritis and Experimental Arthritis Model
Nathan D. Chamberlain 1 , Michael Volin 2 and Shiva Shahrara 1 ,
1
University of Illinois at Chicago, Chicago, IL, 2 Chicago College of
Osteopathic Medicine Midwestern University, Downers Grove, IL
5:45 pm
836. Novel Small Molecule Inhibitors of Interleukin-1 Receptor
Associated Kinase-4 Are Effective in a Preclinical Model of
Arthritis
Eric G. Vajda, Tsung H. Lin, Bojing Wang, Koc-Kan Ho, Arjan
van Oeveren, Brian McGuinness, Jeffrey Letourneau, Yong-
Hee Lee, Deepa Rungta, Lin Zhi and Keith B. Marschke, Ligand
Pharmaceuticals, La Jolla, CA
W375b
Rheumatoid Arthritis Treatment – Small Molecules,
Biologics, Therapy: Biomarkers
Moderators: Michael E. Weinblatt, MD; Immunology and
Allergy, Brigham and Women’s Hospital; Boston, MA
Martin Aringer, MD; Uniklinikum TU Dresden; Dresden, Germany
4:30 pm
837. A Plasmablast Molecular Biomarker for Reduced Clinical
Benefit From Anti-CD20 Therapy in Rheumatoid Arthritis
Kasia Owczarczyk 1 , Preeti Lal 2 , Alexander R. Abbas 1 , Kristen
Wolslegel 1 , Cecile TJ Holweg 1 , Wolfgang Dummer 2 , Ariella
Kelman 2 , Paul Brunetta 2 , Nicholas Lewin-Koh 2 , Marco Sorani 1 ,
Diane Leong 2 , Paul Fielder 1 , David E. Yocum 2 , Carole Ho 2 , Ward
Ortmann 2 , Michael J. Townsend1 and Timothy W. Behrens 2 ,
1
Genentech Research and Early Development, South San
Francisco, CA, 2 Genentech, South San Francisco, CA
4:45 pm
838. Development of a Multi-Biomarker Structural Damage
Score in Rheumatoid Arthritis to Predict Radiographic
Progression in the Leiden Early Arthritis Cohort
Annette H.M. van der Helm-van Mil 1 , Rachel Knevel 1 , William
C. Manning 2 , Lyndal K. Hesterberg 2 , Guy Cavet 2 , T.W.J. Huizinga 3
and Yijing Shen 2 , 1 Leiden University Medical Center, Leiden,
Netherlands, 2 Crescendo Bioscience, Inc., South San Francisco,
CA, 3 Leiden University Medical Centre, Leiden, Netherlands
5:00 pm
839. New Assay Generation for Antibodies Against Modified
and Citrullinated Peptides Predicts Poor Response to TNF
Inhibitor Therapy
Lotta Ljung 1 , Karl Egerer 2 , Holger Bang 3 , Eugen Feist 4 , Gerd R.
Burmester5 and Solbritt Rantapää Dahlqvist 1 , 1 Umeå University
Hospital, Umeå, Sweden, 2 Labor Berlin - Charité Vivantes
GmbH, Berlin, Germany, 3 Orgentec Diagnostika GmbH, Mainz,
Germany, 4 Charité Medical School, Berlin, Germany, 5 Charité -
Universitätsmedizin Berlin, Berlin, Germany
5:15 pm
840. Protein Array Screening Reveals Autoantigenicity Patterns
Predicting Anti-TNF Alpha Therapy Response in Rheumatoid
Arthritis Patients
Zoltan Konthur 1 , Katja Köpke 2 , Hans Lehrach 1 , Gerd R. Burmester 2
and Karl Skriner 2 , 1 Max Planck Institute for Molecular Genetics,