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Many empirical studies have shown highly significant levels of LD, and<br />

often strong associations between nearby SNPs, in the human genome.<br />

Because the likelihood of recombination between two SNPs increases<br />

w<strong>it</strong>h the distance between them, on average such associations between<br />

SNPs decline w<strong>it</strong>h distance.<br />

Average linkage disequilibrium, |D|, vs.<br />

distance between SNPs for 2597<br />

genes in which accurate distances<br />

were available.<br />

Lower values indicate a stronger effect<br />

of recombination and recurrent<br />

mutation.<br />

LD decreases w<strong>it</strong>h distance.<br />

B.A. Salisbury et al. Mutation Research 2003

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