Hap Map Project - Bgbunict.it

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Tandem Repeat Polymorphisms Tandem repeats or variable number of tandem repeats (VNTR) are a very common class of polymorphism, consisting of variable length of sequence motifs that are repeated in tandem in a variable copy number. VNTRs are subdivided into two subgroups based on the size of the tandem repeat units. Microsatellites or Short Tandem Repeat (STR) repeat unit: 1-6 (dinucleotide repeat: CACACACACACA) Minisatellites repeat unit: 10-100
SNPs Sites in the genome where the DNA sequences of many individuals differ by a single base are called single nucleotide polymorphisms (SNPs) For example, some people may have a chromosome with an A at a particular site where others have a chromosome with a G Each form is called an allele
Page 1 and 2: The International HapMap Project An
Page 3 and 4: Genetic and environmental contribut
Page 5 and 6: Discovering these genetic factors w
Page 7: Human Genetic Variations Primarily
Page 11 and 12: Polymorphism A sequence variation t
Page 13 and 14: In principle, SNPs could be bi-, tr
Page 15 and 16: Non-coding SNPs Example: Regulatory
Page 17 and 18: Coding SNPs Example: Non-synonymous
Page 19 and 20: A particular combination of alleles
Page 21 and 22: Linkage disequilibrium Situation i
Page 23 and 24: Many empirical studies have shown h
Page 25: The International HapMap Project is
Page 28 and 29: The HapMap was designed to determin
Page 30 and 31: The International HapMap Consortium
Page 32 and 33: The project had become practical by
Page 34 and 35: The Phase I HapMap Phase I of the H
Page 36 and 37: To study patterns of genetic variat
Page 38 and 39: They estimate that genotypes relate
Page 40 and 41: Genotyping in phase II was attempte
Page 42 and 43: Variation in SNP density within the
Page 44 and 45: Studies in additional populations h
Page 46 and 47: APPLICATION OF THE HAPMAP TO COMMON
Page 48 and 49: The history of high-density GWA sca
Page 50 and 51: A genome-wide association study ide
Page 52 and 53: Beyond SNPs: Copy Number Variants a
Page 54 and 55: Although not as common as SNPs, the
Page 56 and 57: In 2004, the interrogation of genom
Page 58 and 59:
It is now recognized that the genom
Page 60:
Bibliografia The International HapM
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Hap Map Project - Bgbunict.it

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