Hap Map Project - Bgbunict.it
Hap Map Project - Bgbunict.it
Hap Map Project - Bgbunict.it
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Genetic and environmental contributions to monogenic and<br />
complex disorders<br />
(A) Monogenic disease. A variant in a single gene is the primary determinant of a<br />
monogenic disease or tra<strong>it</strong>, responsible for most of the disease risk or tra<strong>it</strong> variation<br />
(dark blue sector), w<strong>it</strong>h possible minor contributions of modifier genes (yellow<br />
sectors) or environment (light blue sector).<br />
(B) Complex disease. Many variants of small effect (yellow sectors) contribute to<br />
disease risk or tra<strong>it</strong> variation, along w<strong>it</strong>h many environmental factors (blue sector).