Mohammed T. Abou-Saleh

CONTENTSviiNutritional Factors in Dementia 210D. N. Anderson and M. T. Abou-SalehEIII Alzheimer’s Disease41 The Genetics of Alzheimer’s Disease 213B. L. Plassman and J. C. S. BreitnerThe Role of Presenilins in Alzheimer’s Disease 217D. M. A. MannApolipoprotein-E (Apo-E) 218D. G. BlazerDown’s Syndrome and Alzheimer’s Disease:Update 219D. W. K. Kay and B. MooreInternational Criteria for Alzheimer’s Diseaseand Their Problems—ICD-10, DSM-IV andNINCS–ADRDA 221K. Rockwood42 The Neuropathology of Alzheimer’s Disease 223D. M. A. MannOxford Project to Investigate Memory andAgeing (OPTIMA): A LongitudinalClinicopathological Study of Dementiaand Normal Ageing 227A. D. SmithConsortium to Establish a Registry forAlzheimer’s Disease (CERAD) 228G. G. Fillenbaum and A. Heyman43 Neurotransmitter Changes in Alzheimer’s Disease:Relationships to Symptoms and Neuropathology 229P. T. Francis and E. K. Perry44 Antemortem Markers 233S. J. Van Rensberg, F. C. V. Potocnikand D. J. Stein45 Clinical Features of Senile Dementia andAlzheimer’s Disease 237B. Pitt46 Assessment and Management of Behavioural andPsychological Symptoms of Dementia (BPSD) 241R. McShane and N. GormleyEating Disorders in Alzheimer’s Disease 245P. E. Cullen and C. BallardEIV Vascular Dementia47 Pathology of Vascular Dementia 247J. M. MacKenzieInternational Criteria for Vascular Dementia andTheir Problems: ICD-10, DSM-IV, ADDTCand NINDS–AIREN 249J. V. Bowler and V. Hachinski48 Vascular Dementia 251P. HumphreyVascular Dementia Subgroups: Multi-infarctDementia and Subcortical White Matter Dementia 255I. SkoogThe Role of Blood Pressure in Dementia 256I. SkoogEV Other Dementias49 Neuropathology: Other Dementias 259J. M. MacKenzie50a Dementia and Parkinson’s Disease 265R. B. Godwin-AustenClinical Criteria for Dementia with Lewy Bodies 268I. G. McKeith50b Subcortical Dementia 269J. R. Burke50c Early-onset Dementias 273G. Mazeika51a Creutzfeldt–Jakob Disease and OtherDegenerative Causes of Dementia 277T. F. G. Esmonde51b Frontotemporal Dementia (Pick’s Disease) 281J. R. Hodges52 Alcoholic and Other Toxic Dementias 285E. M. Joyce53 Reversible Dementias 289M. Philpot and J. PereiraEVI Clinical Diagnosis of the Dementias54 Differential Diagnosis of Dementia 293C. Busby and A. Burns55a Distinguishing Depression from Dementia 297W. E. Fox and D. C. Steffens55b Benign Senescent Forgetfulness, Age-associatedMemory Impairment and Age-related CognitiveDecline 303K. A. Welsh-Bohmer and D. J. MaddenEVII Outcome of the Dementias and Subtypes56 Minor Cognitive Impairment 305K. Ritchie and J. TouchonAlzheimer’s Disease—One or Several? 307C. Holmes and A. H. MannPrognosis of Dementia 308B. Reisberg, A. Kluger and E. FranssenEVIII Treatment and Management of Dementias57 Acute Management of Dementia 313B. Pitt58a Present and Future Treatments of Alzheimer’sDisease 317L. J. Whalley and J. M. Starr58b Possible Future Treatments and PreventativeStrategies for Alzheimer’s Disease 325S. Lovestone59a Psychological and Psychosocial Interventions 327E. Miller59b Informal Carers and Their Support 331D. BuckThe Role and Influence of the Alzheimer’s Society 334N. Graham