Harpers

CATABOLISM OF THE CARBON SKELETONS OF AMINO ACIDS / 261CH 3OOC CH 3 C CH S CoAβ-Methylcrotonyl-CoAH 3 CCHCCCH 3SCoABiotinyl-*CO 2Tiglyl-CoA4L4IH 2 OBiotinO CH 3 OC* C C− O CH 2 CH S CoAβ-Methylglutaconyl-CoAH 2 O5LOOC* H 3 C OH C− O CH 2 CH 2 S CoAβ-Hydroxy-β-methylglutaryl-CoAH 3 CH 3 COCOCHHCHCH 3α-Methyl-β-hydroxybutyryl-CoA5ICHOCOCS[2H]SCoACoAO O 6LC* C− O CH 2 CH3AcetoacetateOCH 3 C S CoAAcetyl-CoAFigure 30–20. Catabolism of the β-methylcrotonyl-CoA formed from L-leucine. Asterisks indicate carbonatoms derived from CO 2 .H 3 COCα-Methylacetoacetyl-CoASCoACH 36I+CH 2CoASHOCSCoACH 3Acetyl-CoA Propionyl-CoAFigure 30–21. Subsequent catabolism of the tiglyl-CoA formed from L-isoleucine.