Harpers

RED & WHITE BLOOD CELLS / 625• The proteinases of neutrophils can digest many tissueproteins; normally, this is kept in check by a batteryof antiproteinases. However, this defense mechanismcan be overcome in certain circumstances, resultingin extensive tissue damage.• The application of recombinant DNA technology isrevolutionizing the field of hematology.REFERENCESBorregaard N, Cowland JB: Granules of the human neutrophilicpolymorphonuclear leukocyte. Blood 1997;89:3503.Daniels G: A century of human blood groups. Wien Klin Wochenschr2001;113:781.Goodnough LT et al: Erythropoietin, iron, and erythropoiesis.Blood 2000;96:823.Hirono A et al: Pyruvate kinase deficiency and other enzymopathiesof the erythrocyte. In: The Metabolic and MolecularBases of Inherited Disease, 8th ed. Scriver CR et al (editors).McGraw-Hill, 2001.Israels LG, Israels ED: Mechanisms in Hematology, 2nd ed. UnivManitoba Press, 1997. (Includes an excellent interactive CD.)Jaffe ER, Hultquist DE: Cytochrome b 5 reductase deficiency andenzymopenic hereditary methemoglobinemia. In: The Metabolicand Molecular Bases of Inherited Disease, 8th ed. ScriverCR et al (editors). McGraw-Hill, 2001.Lekstrom-Hunes JA, Gallin JI: Immunodeficiency diseases causedby defects in granulocytes. N Engl J Med 2000;343:1703.Luzzato L et al: Glucose-6-phosphate dehydrogenase. In: TheMetabolic and Molecular Bases of Inherited Disease, 8th ed.Scriver CR et al (editors). McGraw-Hill, 2001.Rosse WF et al: New Views of Sickle Cell Disease Pathophysiologyand Treatment. The American Society of Hematology.www.asheducationbook.orgTse WT, Lux SE: Hereditary spherocytosis and hereditary elliptocytosis.In: The Molecular Bases of Inherited Disease, 8th ed.Scriver CR et al (editors). McGraw-Hill, 2001.Weatherall DJ et al: The hemoglobinopathies. In: The Metabolicand Molecular Bases of Inherited Disease, 8th ed. Scriver CR etal (editors). McGraw-Hill, 2001.