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4 BIOPOTENTIAL AMPLIFIERSVolumeConductor(Tissue)CurrentfromSourcesVinRinOutputBiopotentialSourceCurrenttoSourcesElectrodeElectrode-TissueInterfaceBiopotentialAmplifier(a)RinterfaceiinBiopotentialSourceVinRinOutputRinterfaceTissue(b)TissueXceiinXinBiopotentialSourceRinReVeElectrodeTissueInterfaceVinXinRinOutputVoutFigure 1.3Xce(c)BiopotentialAmplifier(a) Simplified view of the recording of biopotentials; (b) equivalent circuit; (c) generalized equivalent circuit.
Page 2: DESIGN AND DEVELOPMENTOF MEDICAL EL
Page 8: Copyright © 2005 by John Wiley & S
Page 14: CONTENTSPREFACEDISCLAIMERABOUT THE
Page 20: xPREFACEThe book addresses the prac
Page 26: DISCLAIMERThe projects in this book
Page 30: ABOUT THE AUTHORSDavid Prutchi is V
Page 36: 2 BIOPOTENTIAL AMPLIFIERSGainG70.7%
Page 42: LOW-POLARIZATION SURFACE ELECTRODES
Page 46: SINGLE-ENDED BIOPOTENTIAL AMPLIFIER
Page 50: ULTRAHIGH-IMPEDANCE ELECTRODE BUFFE
Page 54: PASTELESS BIOPOTENTIAL ELECTRODES 1
Page 58: PASTELESS BIOPOTENTIAL ELECTRODES 1
Page 70: 1J2x-1Output X1J2x-21J2y-2Output Y1
Page 74: +9VDriveComSenseJ1-4R247KD31N473871
Page 78: DIFFERENTIAL AMPLIFIERS 23equipment
Page 82: DIFFERENTIAL AMPLIFIERS 25Simple Di
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OP-AMP INSTRUMENTATION AMPLIFIERS 2
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Vout1J3+V32910+-411-+-V114-V+V1IC1A
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2BANDPASS SELECTION FORBIOPOTENTIAL
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WIDEBAND BIOPOTENTIAL AMPLIFIER 43m
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Figure 2.3 The output of the ISO107
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Figure 2.4 Dc and very low frequenc
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PASSIVE FILTERS 49be powered from b
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INVERTING INPUTD2BZD27C11D4BZD27C11
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C50100nFR322.4MR28470KR351.2MR36240
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NOTCH OUTR47100kR48100kR501MR49HIGH
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5V_ISOQ1MMBT2907AR13120R163.3k5V_IS
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ACTIVE FILTERS 59Many good books an
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ACTIVE FILTERS 61we recommend that
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Figure 2.15 A PSpice simulation ac
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50/60-Hz NOTCH FILTERS 65where z is
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Figure 2.17 (Continued)67
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50/60-Hz NOTCH FILTERS 69R1RR3R+12V
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HARMONIC ELIMINATOR 71is equivalent
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The simplified circuit of Figure 2.
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OUTOUTPUTOUTGNDIC1EDR-82534A1. .SIG
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With these warnings in mind, let us
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SWITCHED-CAPACITOR FILTERS 793. Nat
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SLEW-RATE LIMITING 81identification
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ECG AMPLIFIER WITH PACEMAKER PULSE
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+15V141 2IC4ACD40106B32+-+15V4111IC
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frequency of 5.3 kHz. When jumper J
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SCRATCH, RUMBLE, CLICK, AND POP 93+
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REFERENCES 95IC2A and IC2D. At the
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98 DESIGN OF SAFE MEDICAL DEVICE PR
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100 DESIGN OF SAFE MEDICAL DEVICE P
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SIG OUTSIG COM+15PWR COMJ212J312I2F
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112Figure 3.8 The simplest form of
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VoutJ4Non-IsoPower InJ31234+15VISOJ
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KELVINPROBEToDVMBT21.5V "D" CellF11
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PatientConnectionsPatientConnection
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MeasuringDeviceSelectorPatientConne
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15VAC115VAC2ISO 125VACDUT GND SENSE
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+12V+15V+7V-15V-7V+ C176.8uF+ C166.
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117VACHOTNEUTRAL12MAIN ACPOWERSW2SW
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TRIPD61N4148BufferR220k 1.0%Precisi
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148 ELECTROMAGNETIC COMPATIBILITY A
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164Figure 4.11 The intermediate-fre
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Metal BoxHot(Black)L150uHC11.0uF 40
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5SIGNAL CONDITIONING, DATA ACQUISIT
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UNIVERSAL SENSOR INTERFACE 207Figur
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Figure 5.3 Schematic diagram of the
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UNIVERSAL SENSOR INTERFACE 211As co
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UNIVERSAL SENSOR INTERFACE 213dat
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UNIVERSAL SENSOR INTERFACE 215TABLE
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UNIVERSAL SENSOR INTERFACE 217For d
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UNIVERSAL SENSOR INTERFACE 219Figur
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UNIVERSAL SENSOR INTERFACE 22111421
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UNIVERSAL SENSOR INTERFACE 223TO J2
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SAMPLING RATE AND THE NYQUIST THEOR
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FREE DATA ACQUISITION CARD IN YOUR
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OUTOUTGNDTOSOUNDCARDR1C110kR21000.1
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FREE DATA ACQUISITION CARD IN YOUR
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SPECTRAL ANALYSIS 233TABLE 5.4 Some
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SPECTRAL ANALYSIS 235In most instan
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w n x n e 2πjf n ∆t X( f ) ∆t
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SPECTRAL ANALYSIS 239High-Resolutio
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SPECTRAL ANALYSIS 241Figure 5.19 Po
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SPECTRAL ANALYSIS 243order, but an
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SPECTRAL ANALYSIS 245Figure 5.21 A
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REFERENCES 247apart over the biceps
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250 SIGNAL SOURCES FOR SIMULATION,
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OUTPUTJ2SMBR10502WJP1JUMPER 3JP2JUM
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T112VAC 1AD11N4005D31N4005+ C45+220
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C791uFR112Z_SIG_OUTZ Amplitude~0-50
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294Figure 6.31 A potentiostat-galva
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7STIMULATION OF EXCITABLE TISSUESAn
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STIMULATION OF EXCITABLE TISSUES 30
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EXTRACELLULAR STIMULATION 309membra
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CLINICAL USES OF ELECTRICAL STIMULA
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9. Control of Parkinsonian tremor.
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TABLE 7.1(Continued)CLINICAL USES O
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DIRECT STIMULATION OF NERVE AND MUS
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ELECTRODE 1ELECTRODE 2I_OUTR3+15V_S
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WAVEFORM:CLOSED = MONOPHASICOPEN =
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BT1 BT2 BT3 BT41.5V1.5V1.5V1.5VSW1P
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ELECTRODE 3BODY PARTTO BESTIMULATED
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• Cardiac demand pacemakers that
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MAGNETIC STIMULATION 347trast, a ma
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SCR1ST330S16P0L1COILEXTREME DANGER!
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MAGNETIC STIMULATION 351• TOFF: t
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MAGNETIC STIMULATION 353+ -d/dtCOIL
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MAGNETIC STIMULATION 355tube cap. A
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OTHER CLINICAL APPLICATIONS OF ELEC
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Hodgkin, A. L., and A. F. Huxley, A
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8CARDIAC PACING AND DEFIBRILLATIONW
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BRADYARRHYTHMIAS 371As a result, on
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THE FIRST PACEMAKERS 373designed in
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Figure 8.4 The output of a PSpice s
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THE FIRST PACEMAKERS 377V SenseA Se
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Pacing Mode This parameter selects
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EXTERNAL VVI PACEMAKER 381EXTERNAL
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Figure 8.11 presents the schematic
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VDDV+AnodeACTI VE_DISCHARGEQ1BSS84R
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EXTERNAL VVI PACEMAKER 387TimeStamp
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EXTERNAL VVI PACEMAKER 389}}default
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SOFTWARE TESTING 391Of course, safe
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IMPEDANCE TECHNIQUE 393contraction)
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IMPEDANCE TECHNIQUE 395
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IMPEDANCE TECHNIQUE 397C110.1uFR205
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DEMOD_OUT+15Viso-15VisoINPUTJ5SMC39
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INTRACARDIAC IMPEDANCE SENSOR 401Le
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INTRACARDIAC IMPEDANCE SENSOR 403At
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INTRACARDIAC IMPEDANCE SENSOR 405Fi
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VENTRICULAR TACHYARRHYTHMIAS 407Tim
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1.61.41.2Output Voltage10.80.60.4DV
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VENTRICULAR TACHYARRHYTHMIAS 411Imp
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DEFIBRILLATION 413stimulus waveform
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SW5Safety InterlockF12AF20.25ASW1Po
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SHOCK BOX PROTOTYPE 417defibrillati
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SHOCK BOX PROTOTYPE 419Figure 8.34
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Figure 8.36 Interconnection diagram
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SHOCK BOX PROTOTYPE 423In operation
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SHOCK BOX PROTOTYPE 425markets and
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Figure 8.40 A H-bridge switch confi
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SHOCK BOX PROTOTYPE 429V_CAP_OUTR56
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SHOCK BOX PROTOTYPE 431onboard the
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SHOCK BOX PROTOTYPE 433+12_VBATC791
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SHOCK BOX PROTOTYPE 435value by the
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CARDIAC FIBRILLATOR 4373. Every 1 s
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CONCLUDING REMARKS 439+9VS1R1IC15CO
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EPILOGUEOut of clutter, find simpli
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PATH THROUGH THE FDA 443intended us
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the industry is undergoing profound
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APPENDIX ASOURCES FOR MATERIALS AND
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SOURCES FOR MATERIALS AND COMPONENT
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APPENDIX BFTP SITE CONTENTftp://ftp
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FTP SITE CONTENT 453• LPT8FAST.BA
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FTP SITE CONTENT 455Folder: Redistr
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458 INDEXCentro de Construccion de
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460 INDEXPacemaker(s) (Continued)pu
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