DESIGN AND DEVELOPMENT OF MEDICAL ELECTRONIC ...

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ELECTRODE 1ELECTRODE 2I_OUTR3+15V_SWITCHED1M +15V_SWITCHEDR21MR125kR41MC30.01uFC40.01uF74268C60.01uF+5V_SWITCHEDIC1ICM7555/TO5 3CONTVO UTDISCHRESETTRIGTHOLDV+1+5V416132JKCLKCLRPREIC2A74C76IC3AQQ1 274C04151412R5100kR7100kR11100kIC5UPC4250C70.01uF3245IC4A74C08IC4B74C08367+-4 86R91MC20.01uF-15V_ SWITCHEDR62MR102MC11uF+C51uF+327+-4 8R81MGND-15V_SWITCHEDR12IC6UPC42506+5V_SWITCHEDR131M+15V+15V_SWITCHED100k-15V-15V_SWITCHED+5V+5V_SWITCHED30s to 4min30s to 4min30min to 20hoursFigure 7.12 In this symmetric biphasic current stimulator, pulses generated by timer IC1 are reshaped by IC2A, IC3A, IC4A, IC4B, andIC5 into a symmetric bipolar square-pulse train. The resulting voltage waveform is converted into a constant-current waveform by the invertingHowland current pump built around IC6. Livnat et al. [1981] used implanted electrodes and this output stage for chronic stimulation ofthe central nervous system.323
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DESIGN AND DEVELOPMENTOF MEDICAL EL
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Copyright © 2005 by John Wiley & S
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CONTENTSPREFACEDISCLAIMERABOUT THE
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xPREFACEThe book addresses the prac
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DISCLAIMERThe projects in this book
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ABOUT THE AUTHORSDavid Prutchi is V
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2 BIOPOTENTIAL AMPLIFIERSGainG70.7%
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4 BIOPOTENTIAL AMPLIFIERSVolumeCond
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6 BIOPOTENTIAL AMPLIFIERSWarning! T
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8 BIOPOTENTIAL AMPLIFIERSIfRf-VccRi
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10 BIOPOTENTIAL AMPLIFIERSFigure 1.
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12 BIOPOTENTIAL AMPLIFIERSof the sk
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14 BIOPOTENTIAL AMPLIFIERScontamina
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20 BIOPOTENTIAL AMPLIFIERSA way of
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22 BIOPOTENTIAL AMPLIFIERSskin- ele
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26 BIOPOTENTIAL AMPLIFIERSOscillosc
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28 BIOPOTENTIAL AMPLIFIERS+15VV 132
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X1KX100X10JP2Sense3 2 13 2 14 5 6JP
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32 BIOPOTENTIAL AMPLIFIERSgenerator
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36 BIOPOTENTIAL AMPLIFIERSresults i
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38 BIOPOTENTIAL AMPLIFIERSUsing off
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42 BANDPASS SELECTION FOR BIOPOTENT
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5V_ISOIR25.1MR35.1MIR11M2374 8-+65V
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62Figure 2.14 State-variable filter
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64Figure 2.16 Since the cutoff freq
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66Figure 2.17 PSpice simulation res
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OUTOutputOut GND6R42kIC 1UAF42 8Hig
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-OUTOUTGNDININPUTINGND11R5100k1213+
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86Figure 2.35 The slew-rate limiter
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J3OUTPUTBNC2CR81.05KIC 2C406654 3LP
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IC5DCD4093B11CDisplay_InAD131N41484
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OUT+5V_ISOC122uF3284+-IC1A1OPA2130+
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3DESIGN OF SAFE MEDICALDEVICE PROTO
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STANDARDS FOR PROTECTION AGAINST EL
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LEAKAGE CURRENTS 1011. Ground leaka
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Figure 3.2 A universal differential
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DESIGN EXAMPLE: ISOLATED DIFFERENTI
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-15VC6+15VC5.01uFIC2.01uF UA741 -15
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ANALOG SIGNAL ISOLATION USING OPTIC
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LINEAR ANALOG ISOLATION USING OPTOI
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LINEAR ANALOG ISOLATION USING OPTOI
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NON ISO.POWERSignalOutputJP312ISO.P
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ISOLATEDPOWERINPUTJ4ISOLATED SIDENO
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DIGITAL ALTERNATIVE TO SIGNAL ISOLA
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SOFTWARE FOR THE ISOLATED A/D 121LP
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POWER SUPPLIES 123Figure 3.17 The n
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ADDITIONAL PROTECTION 125In additio
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TESTING FOR COMPLIANCE 127designed
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TESTING FOR COMPLIANCE 129Voltage-M
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TESTING FOR COMPLIANCE 131The frequ
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SelectorSelectorPatientConnectionsP
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+V_LCD-V_LCDC110.01uFR1462kR1362kC6
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ISOLATED 125 VACAC BALANCE125VAC TO
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TABLE 3.3 Normal and Fault Conditio
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TESTING FOR COMPLIANCE 141TABLE 3.4
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TESTING FOR COMPLIANCE 143HI-POTHV
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TESTING FOR COMPLIANCE 145that diel
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4ELECTROMAGNETIC COMPATIBILITYAND M
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RADIATED EMISSIONS FROM DIGITAL CIR
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RADIATED EMISSIONS FROM DIGITAL CIR
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+24VISOC6100nFIsoC12100nFIso15IC1+V
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ELECTROMAGNETIC FIELDS 155TABLE 4.3
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ELECTROMAGNETIC FIELDS 157andIlH(A/
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PROBING E- AND H-FIELDS IN THE NEAR
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BARE-BONES SPECTRUM ANALYZER 161mag
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45MHz_IFR813R982L2L1LOFREQUENCYADJU
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single-chip IF processor, takes car
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CONDUCTED EMISSIONS 167J2BNC1220MHz
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CONDUCTED EMISSIONS 169LISN40 cmLIS
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SUSCEPTIBILITY 171TABLE 4.4EN-55011
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SUSCEPTIBILITY 173The human body mo
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SUSCEPTIBILITY 175Gas delivery tube
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SUSCEPTIBILITY 177the user that the
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SUSCEPTIBILITY 179Figure 4.22 A pro
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SUSCEPTIBILITY 181+12VSW 1*= Heatsi
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SUSCEPTIBILITY 183Ground PlaneContr
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J2To D evi ceUnd er Te stAC Power P
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SUSCEPTIBILITY 187mode after a prol
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GOOD DESIGN PRACTICES, REMEDIES, AN
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REFERENCES 203REFERENCESDash, G., a
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206 SIGNAL CONDITIONING, DATA ACQUI
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SCLKDOUT*CSMUXD0MUXD1MUXD2ANALOG TO
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210Figure 5.4 Timing diagram for th
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TO J1UNIVERSALSENSORINTERFACECONNEC
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+C110uFC20.1uFR1100k+12VR2C30.01uFI
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6SIGNAL SOURCES FOR SIMULATION,TEST
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OUTPUTSW1C11uF,25VC30.1uF++15V-15VC
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15+12V+12V147147TRIGGERCLOCKADJUSTC
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DIGITAL GENERATION OF ANALOG WAVEFO
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DIGITAL GENERATION OF ANALOG WAVEFO
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ARB BASICS 259TABLE 6.2 Input Lines
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ARB BASICS 261If more than sufficie
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ARB BASICS 263Figure 6.11 The addre
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D[0:31]D[0:31]+5VSW2R4510kJ3BNCCLK_
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CLK_LOCALC330.022uFC342200pFSW3200k
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ARB BASICS 269Finally, a word of ca
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ARB BASICS 271complex waveform can
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ARB BASICS 273design package such a
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OUTOUTPUTOUTGNDIC1BTL0847-5V+5V+5V+
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RESPONSIVE SIMULATORS 277Figure 6.1
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Figure 6.21 Right-atrial and right-
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+15VCLKDINIC31LTC1451VCCVOUT+5VC390
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RESPONSIVE SIMULATORS 283IC40B scal
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Figure 6.26 This bar graph display
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RESPONSIVE SIMULATORS 287A EventDet
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RESPONSIVE SIMULATORS 289relatively
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Figure 6.30 A torso simulator model
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Experimental validation studies for
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RESPONSIVE SIMULATORS 295One Telede
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Page 630: VERY REALISTIC PHYSIOLOGICAL SIGNAL
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Page 638: REFERENCES 303We believe that exper
Page 644: 306 STIMULATION OF EXCITABLE TISSUE
Page 682: DIRECT STIMULATION OF NERVE AND MUS
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Page 726: MAGNETIC STIMULATION 347trast, a ma
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SCR1ST330S16P0L1COILEXTREME DANGER!
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MAGNETIC STIMULATION 351• TOFF: t
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MAGNETIC STIMULATION 353+ -d/dtCOIL
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MAGNETIC STIMULATION 355tube cap. A
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OTHER CLINICAL APPLICATIONS OF ELEC
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Hodgkin, A. L., and A. F. Huxley, A
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8CARDIAC PACING AND DEFIBRILLATIONW
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BRADYARRHYTHMIAS 371As a result, on
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THE FIRST PACEMAKERS 373designed in
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Figure 8.4 The output of a PSpice s
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THE FIRST PACEMAKERS 377V SenseA Se
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Pacing Mode This parameter selects
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EXTERNAL VVI PACEMAKER 381EXTERNAL
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Figure 8.11 presents the schematic
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VDDV+AnodeACTI VE_DISCHARGEQ1BSS84R
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EXTERNAL VVI PACEMAKER 387TimeStamp
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EXTERNAL VVI PACEMAKER 389}}default
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SOFTWARE TESTING 391Of course, safe
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IMPEDANCE TECHNIQUE 393contraction)
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IMPEDANCE TECHNIQUE 395
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IMPEDANCE TECHNIQUE 397C110.1uFR205
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DEMOD_OUT+15Viso-15VisoINPUTJ5SMC39
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INTRACARDIAC IMPEDANCE SENSOR 401Le
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INTRACARDIAC IMPEDANCE SENSOR 403At
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INTRACARDIAC IMPEDANCE SENSOR 405Fi
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VENTRICULAR TACHYARRHYTHMIAS 407Tim
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1.61.41.2Output Voltage10.80.60.4DV
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VENTRICULAR TACHYARRHYTHMIAS 411Imp
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DEFIBRILLATION 413stimulus waveform
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SW5Safety InterlockF12AF20.25ASW1Po
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SHOCK BOX PROTOTYPE 417defibrillati
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SHOCK BOX PROTOTYPE 419Figure 8.34
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Figure 8.36 Interconnection diagram
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SHOCK BOX PROTOTYPE 423In operation
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SHOCK BOX PROTOTYPE 425markets and
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Figure 8.40 A H-bridge switch confi
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SHOCK BOX PROTOTYPE 429V_CAP_OUTR56
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SHOCK BOX PROTOTYPE 431onboard the
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SHOCK BOX PROTOTYPE 433+12_VBATC791
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SHOCK BOX PROTOTYPE 435value by the
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CARDIAC FIBRILLATOR 4373. Every 1 s
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CONCLUDING REMARKS 439+9VS1R1IC15CO
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EPILOGUEOut of clutter, find simpli
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PATH THROUGH THE FDA 443intended us
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the industry is undergoing profound
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APPENDIX ASOURCES FOR MATERIALS AND
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SOURCES FOR MATERIALS AND COMPONENT
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APPENDIX BFTP SITE CONTENTftp://ftp
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FTP SITE CONTENT 453• LPT8FAST.BA
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FTP SITE CONTENT 455Folder: Redistr
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458 INDEXCentro de Construccion de
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460 INDEXPacemaker(s) (Continued)pu
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