Literature Review: Pregnant and breastfeeding ... - Eat For Health

Reference Spector 2005Dietary patterns Fruit and vegetables: VF+ = DNAt2 inhibitor containing foods (fresh and canned fruit and vegetables, canned or dried legumes, soy (either soy sauce orother soy), coffee, black tea, green tea, cocoa, red wine, and other caffeinated beverages)Study typeCase-control studyLevel of evidence III-3 (aetiology)SettingUSA (126 Children’s Oncology Groups)FundingNational Cancer Institute, USA and Children’s Cancer Research FundParticipants240 cases diagnosed during 1996 and 2002 (149 ALL and 91 AML);255 controls selected by random digit diallingBaseline comparisons See confounding belowDietary assessment FFQTimingAdministered to reflect entirety of pregnancyComparisonVF+ (quartiles)OutcomesInfant acute leukemia (AML) and childhood acute lymphoblastic leukemia (ALL)ResultsControls ALL cases ALL aOR (95% CI) AML cases AML aOR (95% CI) Total aOR (95% CI)Q1 53 46 1 25 1 1Q2 67 37 0.7 (0.4 to 1.2) 20 0.6 (0.3 to 1.2) 0.6 (0.4 to 1.0)Q3 68 28 0.5 (0.3 to 0.9) 27 0.8 (0.4 to 1.6) 0.6 (0.4 to 1.0)Q4 27 37 0.7 (0.4 to 1.2) 19 0.6 (0.3 to 1.2) 0.6 (0.4 to 1.0)P trend 0.09 0.18 0.05FollowupConfoundingRisk of biasRelevanceOther commentsNAAdjusted for mother’s age at birth of index child, income and education, and infant’s race and sexLow-moderate risk of bias: Of the 348 potential cases identified, 240 (69%) maternal interviews were successfully completed (missing data includedmaternal refusal (17%), physician refusal (7%), and inability to locate mother (7%);67% response rate for controlsLikely to be relevant to Australian womenFresh fruits (r = 0.66), fresh vegetables (r = 0.69) and canned vegetables (r = 0.60) were the components most highly with the VF+ indexFruit and Vegetables399