Literature Review: Pregnant and breastfeeding ... - Eat For Health

Reference Maconochie 2007Food groupsLegumes (soy products)Study typeCase-control study (postal survey sampled from the electoral roll – National Women’s Health Study)Level of evidence III-3 (aetiology)SettingUK general populationFundingNational Lottery Community Fund, Miscarriage AssociationParticipantsCases: 603 women aged 18 to 55 years whose most recent pregnancy had ended in first trimester miscarriage (< 13 weeks gestation);Controls: 6116 women aged 18 to 55 years whose most recent pregnancy had progressed beyond 12 weeksBaselineComparisonsBMI < 18.5 was significantly associated with odds of miscarriageAlso see Confounding belowDietary Assessment questionnaireTimingDiet in the three months prior to conception and the first 12 weeks of pregnancyComparisonDaily or most daysOutcomesFirst trimester miscarriageResultsSoy products daily or most daysCases Controls aOR (95% CI) aOR further adjusted for nauseaNo 566 (97%) 5783 (97%) 1.00 1.00Yes 20 (3%) 175 (3%) 0.99 (0.61 to 1.59) 1.06 (0.66 to 1.70)Length of followup n/aConfoundingAdjusted for year of conception, maternal age, previous miscarriage and previous live birth; and further adjusted for nausea in the first 12 weeks ofpregnancyRisk of bias Low risk of bias: 88% of eligible women responding to stage 1 agreed to participate in the second stage of the study; and 71% responded to the stage 2questionnaire. 1071/7790 records (7508 women) were excluded (mostly due to index pregnancy being conceived prior to 1980), leaving 6719 records(86%) available for analysisRelevanceLikely to be relevant to Australian womenOther comments Women who suffered from nausea in the first 12 weeks of pregnancy were almost 70% less likely to miscarryLegumes411