98Soybean and HealthHatch, F. T., Knize, M. G. & Colvin, M. E. (2001). Extended quantitative structure-activityrelationships for 80 aromatic and heterocyclic amines: structural, electronic, andhydropathic factors affecting mutagenic potency. Environmental and MolecularMutagenesis, Vol. 38, No. 4, pp. 268-91, ISSN 0893-6692Hemnani, T. & Parihar, M. S. (1998). Reactive oxygen species and oxidative DNA damage.Indian Journal <strong>of</strong> Physiology and Pharmacology, Vol. 42, No. 4, (October 1998), pp. 440-52, ISSN 0019-5499Henderson, L., Wolfreys, A., Fedyk, J., Bourner, C. & Windebank, S. (1998). The ability <strong>of</strong> theComet assay to discriminate between genotoxins and cytotoxins. Mutagenesis, Vol.13, No. 1, (March 1998), pp. 89-94, ISSN 0267-8357Hoeijmakers, J. H. (2001). Genome maintenance mechanisms for preventing cancer. Nature,Vol. 411, No. 6835, (May 2001), pp. 366-74, ISSN 0028-0836Hollman, P. C. H., Hertog, M. G. L. & Katan, M. B. (1996). Analysis and health effects <strong>of</strong>flavonoids. Food Chemistry, Vol. 57, No. 1, pp. 43-46, .Hopkins, M. H., Fedirko, V., Jones, D. P., Terry, P. D. & Bostick, R. M. (2010). Antioxidantmicronutrients and biomarkers <strong>of</strong> oxidative stress and inflammation in colorectaladenoma patients: results from a randomized, controlled clinical trial. CancerEpidemiology, Biomarkers & Prevention, Vol. 19, No. 3, (March 2010), pp. 850-8, ISSN1538-7755Hursting, S. D., Lavigne, J. A., Berrigan, D., Perkins, S. N. & Barrett, J. C. (2003). Calorierestriction, aging, and cancer prevention: mechanisms <strong>of</strong> action and applicability tohumans. Annual Review <strong>of</strong> Medicine, Vol. 54, pp. 131-52, ISSN 0066-4219IARC. (1993). Monographs on the evaluation <strong>of</strong> carcinogenic risks to human: some naturallyoccurring substances: food items and constituents, heterocyclic aromatic aminesand mycotoxins. No. 56, pp. 165-229Jiricny, J. & Marra, G. (2003). DNA repair defects in colon cancer. Current Opinion in Genetics& Development, Vol. 13, No. 1, (February 2003), pp. 61-9, ISSN 0959-437XKaur, G., Roberti, M., Raul, F. & Pendurthi, U. R. (2007). Suppression <strong>of</strong> human monocytetissue factor induction by red wine phenolics and synthetic derivatives <strong>of</strong>resveratrol. Thrombosis Research, Vol. 119, No. 2, pp. 247-56, ISSN 0049-3848King, C. M., Gillespie, E. S., McKenna, P. G. & Barnett, Y. A. (1994). An investigation <strong>of</strong>mutation as a function <strong>of</strong> age in humans. Mutation Research, Vol. 316, No. 2,(August 1994), pp. 79-90, ISSN 0027-5107Knasmuller, S., Steinkellner, H., Hirschl, A. M., Rabot, S., Nobis, E. C. & Kassie, F. (2001).Impact <strong>of</strong> bacteria in dairy products and <strong>of</strong> the intestinal micr<strong>of</strong>lora on thegenotoxic and carcinogenic effects <strong>of</strong> heterocyclic aromatic amines. MutationResearch, Vol. 480-481, (September 2001), pp. 129-38, ISSN 0027-5107Knize, M. G., Dolbeare, F. A., Cunningham, P. L. & Felton, J. S. (1995). Mutagenic activityand heterocyclic amine content <strong>of</strong> the human diet. Princess Takamatsu Symposia, Vol.23, pp. 30-8Knize, M. G. & Felton, J. S. (2005). Formation and human risk <strong>of</strong> carcinogenic heterocyclicamines formed from natural precursors in meat. Nutrition Reviews, Vol. 63, No. 5,(May 2005), pp. 158-65, ISSN 0029-6643Kruidenier, L., Kuiper, I., Lamers, C. B. & Verspaget, H. W. (2003). Intestinal oxidativedamage in inflammatory bowel disease: semi-quantification, localization, andassociation with mucosal antioxidants. The Journal <strong>of</strong> Pathology, Vol. 201, No. 1,(September 2003), pp. 28-36Krul, C., Luiten-Schuite, A., Baandagger, R., Verhagen, H., Mohn, G., Feron, V. & Havenaar,R. (2000). Application <strong>of</strong> a dynamic in vitro gastrointestinal tract model to study the
The Effect <strong>of</strong> Flavonoids in Soybean Products in Lymphocytes from IBDand Colon Cancer Patients After Treatment with Food Mutagens and Hydrogen Peroxide 99availability <strong>of</strong> food mutagens, using heterocyclic aromatic amines as modelcompounds. Food and Chemical Toxicology, Vol. 38, No. 9, (September 2000), pp. 783-92, ISSN 0278-6915Kumaravel, T. S. & Jha, A. N. (2006). Reliable Comet assay measurements for detecting DNAdamage induced by ionising radiation and chemicals. Mutation Research, Vol. 605,No. 1-2, (June 2006), pp. 7-16, ISSN 0027-5107Kumaravel, T. S., Vilhar, B., Faux, S. P. & Jha, A. N. (2009). Comet Assay measurements: aperspective. Cell Biology and Toxicology, Vol. 25, (November 2007), pp. 53-64Lakshmi, V. M., Hsu, F. F. & Zenser, T. V. (2008). N-Demethylation is a major route <strong>of</strong> 2-amino-3-methylimidazo[4,5-f]quinoline metabolism in mouse. Drug Metabolism andDisposition: the biological fate <strong>of</strong> chemicals, Vol. 36, No. 6, (June 2008), pp. 1143-52,ISSN 1521-009XLee, J. C., Kim, J., Park, J. K., Chung, G. H. & Jang, Y. S. (2003). The antioxidant, rather thanprooxidant, activities <strong>of</strong> quercetin on normal cells: quercetin protects mousethymocytes from glucose oxidase-mediated apoptosis. Experimental Cell Research,Vol. 291, No. 2, (December 2003), pp. 386-97Lodovici, M. & Bigagli, E. (2009). Biomarkers <strong>of</strong> induced active and passive smokingdamage. International Journal <strong>of</strong> Environmental Research and Public Health, Vol. 6, No.3, (March 2009), pp. 874-88, ISSN 1660-4601Loguercio, C., D'Argenio, G., Delle Cave, M., Cosenza, V., Della Valle, N., Mazzacca, G. &del Vecchio Blanco, C. (1996). Direct evidence <strong>of</strong> oxidative damage in acute andchronic phases <strong>of</strong> experimental colitis in rats. Digestive Diseases and Sciences, Vol. 41,No. 6, (June 1996), pp. 1204-11, ISSN 0163-2116Maeda, H., Sawa, T., Yubisui, T. & Akaike, T. (1999). Free radical generation fromheterocyclic amines by cytochrome b5 reductase in the presence <strong>of</strong> NADH. CancerLetters, Vol. 143, No. 2, (September 1999), pp. 117-21, ISSN 0304-3835Mendoza-Nunez, V. M., Sanchez-Rodriguez, M. A., Retana-Ugalde, R., Vargas-Guadarrama,L. A. & Altamirano-Lozano, M. A. (2001). Total antioxidant levels, gender, and ageas risk factors for DNA damage in lymphocytes <strong>of</strong> the elderly. Mechanisms <strong>of</strong> Ageingand Development, Vol. 122, No. 8, (June 2001), pp. 835-47, ISSN 0047-6374Messner, C. & Murkovic, M. (2004). Evaluation <strong>of</strong> a new model system for studying theformation <strong>of</strong> heterocyclic amines. Journal <strong>of</strong> Chromatography. B, Analytical Technologies inthe Biomedical and Life Sciences, Vol. 802, No. 1, (March 2004), pp. 19-26, ISSN 1570-0232Moller, P. (2006). The alkaline comet assay: towards validation in biomonitoring <strong>of</strong> DNAdamaging exposures. Basic & Clinical Pharmacology & Toxicology, Vol. 98, No. 4,(April 2006), pp. 336-45, ISSN 1742-7835Murata, M., Kobayashi, M. & Kawanishi, S. (1999). Mechanism <strong>of</strong> oxidative DNA damageinduced by a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5f]quinoxaline.Japanese Journal <strong>of</strong> Cancer Research, Vol. 90, No. 3, (March 1999), pp. 268-75, ISSN0910-5050Murtaugh, M. A., Ma, K. N., Sweeney, C., Caan, B. J. & Slattery, M. L. (2004). Meatconsumption patterns and preparation, genetic variants <strong>of</strong> metabolic enzymes, andtheir association with rectal cancer in men and women. The Journal <strong>of</strong> Nutrition, Vol.134, No. 4, (April 2004), pp. 776-84, ISSN 0022-3166Nagao, M., Ushijima, T., Toyota, M., Inoue, R. & Sugimura, T. (1997). Genetic changesinduced by heterocyclic amines. Mutation Research, Vol. 376, No. 1-2, (May 1997),pp. 161-7, ISSN 0027-5107
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PrefaceWorldwide, soybean seed prot
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Soybean Products Consumption in the
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20Soybean and HealthWagner, J.D., A
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22Soybean and HealthDifferences in
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24Soybean and Healthfermented chung
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26Soybean and HealthIsoflavones, wh
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28Soybean and HealthThe concentrati
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30Soybean and Health5. Metabolite p
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32Soybean and Healththat various me
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34Soybean and Healtheffects on hypo
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36Soybean and Healthfatty acid oxid
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38Soybean and HealthThe decreased n
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40Soybean and Healththe N-terminus
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42Soybean and HealthYAVE, IVAE, LVA
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44Soybean and Healthrespectively, w
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46Soybean and HealthIn order to des
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Insights into the Pharmacological E
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Insights into the Pharmacological E
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9Occurrence of Biogenic Aminesin So
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Occurrence of Biogenic Amines in So
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10Biologically Active Molecules fro
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11From Soybean Phytosterolsto Stero
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From Soybean Phytosterols to Steroi
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From Soybean Phytosterols to Steroi
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From Soybean Phytosterols to Steroi
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From Soybean Phytosterols to Steroi
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12Genistein Derivatization - From a
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13Soybean Oil: Production Process,
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14Beneficial Effects of Bioactive P
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15Soy Isoflavones as BioactiveIngre
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16Soybean Oil: How Good or How Bad
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17Anti-Diarrhoeal Aspectsof Ferment
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18Antioxidant and Hypocholesterolem
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19Important Minor Soybens Proteins:
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Important Minor Soybens Proteins: S
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20Soybean Allergens: Presence, Dete
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21Nutritional and Bioactive Compoun
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22Polyamines - The Principal Candid
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Polyamines - The Principal Candidat