348Soybean and HealthDuncan, A.M., Merz-Demlow, B.E., Xu, X., Phipps, W.R. & Kurzer, M.S. (2000).Premenopausal equol excretors show plasma hormone pr<strong>of</strong>iles associated withlowered risk <strong>of</strong> breast cancer. Cancer Epidemiology, Biomarkers and Prevention, Vol. 9,No.6, (June 2000), pp. 581-586, ISSN 1055-9965.European Food Safety Agency. (2006). Scientific Opinion on the substantiation <strong>of</strong> a healthclaim related to soy protein and reduction <strong>of</strong> blood cholesterol concentrationspursuant to Article 14 <strong>of</strong> the Regulation (EC) No 1924/2006, Published: 30 July2010.Eldridge, A.C. & Kwolek, W.F. (1983). Soybean is<strong>of</strong>lavones: effects <strong>of</strong> environment andvariety on composition. Journal <strong>of</strong> Agricultural and Food Chemistry, Vol. 31, No. 2,(March 1983), pp. 394-396, ISSN 0021-8561.Erdman, J.W. Jr, Badger, T.M., Lampe, J.W., Setchell, K.D.R. & Messina, M. (2004). Not allsoy products are created equal: caution needed in interpretation <strong>of</strong> research results.Journal <strong>of</strong> Nutrition, Vol. 134, No. 5, (May 2004), pp. S1229–S1233, ISSN 0022-3166.Fardet, A., Llorach, R., Orsoni, A., Martin, J-F., Pujos-Guillot, E., Lapierre, C. & Scalbert, A.(2008). Metabolomics provide new insight on the metabolism <strong>of</strong> dietaryphytochemicals in rats. Journal <strong>of</strong> Nutrition, Vol. 138, No. 7, (July 2008), pp. 1282–1287, ISSN 0022-3166.Faughnan, M.S., Hawdon, A., Ah-Singh, E., Brown, J., Millward, D.J. & Cassidy, A. (2004).Urinary is<strong>of</strong>lavone kinetics: the effect <strong>of</strong> age, gender, food matrix and chemicalcomposition. British Journal <strong>of</strong> Nutrition, Vol. 91, No. 4, (April 2004), pp. 567–574,ISSN 0007-1145.Fleiszig, S.M.J. & Evans, D.J. (1999). Methods for inhibiting bacterial cytotoxicity. US patent5,948,815. September 7.Food and Drug Administration. (1999). Health and Human Services: Food labeling: healthclaims; soy protein and coronary heart disease. Final rule. Federal Register, Vol. 64,No. 206, (October 1999), pp. 57700–57733, ISSN 0097–6326.Fraga, C.G., Galleano, M., Verstraeten, S.V. & Oteiza, P.I. (2010). Basic biochemicalmechanisms behind the health benefits <strong>of</strong> polyphenols. Molecular Aspects <strong>of</strong>Medicine, Vol. 31, No. 6, (December 2010), pp. 435–445, ISSN 0098-2997.Frank, A.A., Hankin, J.H., Yu, M.C., Maskarinec, G., Low, S.H. & Custer, L.J. (1999).Is<strong>of</strong>lavone level in soy foods consumed by multiethnic populations in Singaporeand Hawaii. Journal <strong>of</strong> Agricultural and Food Chemistry, Vol. 7, No. 3, (March 1999),pp. 977-986, ISSN 0021-8561.Franke, A.A., Halm, B.M., Kakazu, K., Li, X. & Custer, L.J. (2009). Phytoestrogenicis<strong>of</strong>lavonoids in epidemiologic and clinical research. Drug Testing and Analysis, Vol.1, No.1, (January 2009), pp.14–21, ISSN 1942-7603.Fukutake, M., Takahashi, M., Ishida, K., Kawamura, H., Sugimura, T. & Wakabayashi, K.(1996). Quantification <strong>of</strong> genistein and genistin in soybeans and soybean products.Food and Chemical Toxicology, Vol. 34, No. 5, (May 1996), pp. 457–461, ISSN 0278-6915.Garrido, A., De la Maza, M.P., Hirsch, S. & Valladares, L. (2006). Soy is<strong>of</strong>lavones affectplatelet thromboxane A2 receptor density but not plasma lipids in menopausalwomen. Maturitas, Vol. 54, No. 3, (June 2006), pp. 270-276, ISSN 1521-690X.
Soy Is<strong>of</strong>lavones as Bioactive Ingredients <strong>of</strong> Functional Foods 349Gee, J.M., Noteborn, H.P.J.M., Polley, A.C.J. & Johnson, I.T. (2000). Increased induction <strong>of</strong>aberrant crypt foci by 1,2-dimethylhydrazine in rats fed diets containing purifiedgenistein or genistein-rich soya protein. Carcinogenesis, Vol. 21, No. 12, (December2000), pp.2255–2259, ISSN 0143-3334.Genovese, M.I. & Lajolo, F. (2010). Soy Protein Ingredients as Is<strong>of</strong>lavone Sources forFunctional Foods. K. R. Cadwallader & S.K.C. Chang (eds). Chemistry, Texture, andFlavor <strong>of</strong> Soy. ACS Symposium Series, Vol. 1059, pp. 189–200, ISBN 9780841225619,Washington, D.C.Gibney, M.J., Walsh, M., Brennan, L., Roche, H.M., German, B. & van Ommen, B. (2005).Metabolomics in human nutrition: opportunities and challenges. American Journal <strong>of</strong>Clinical Nutrition, Vol. 82, No. 3, (September 2005), pp. 497-503, ISSN 0002-9165.Gottstein, N., Ewins, B.A., Eccleston, C., Hubbard, G.P., Kavanagh, I.C., Minihane, A.M.,Weinberg, P.D. & Rimbach, G. (2003). Effect <strong>of</strong> genistein and daidzein on plateletaggregation and monocyte and endothelial function. British Journal <strong>of</strong> Nutrition, Vol.89, No. 5, (May 2003), pp. 607-616, ISSN 0007-1145.Gu, L., House, S.E., Prior, R.L., Fang, N., Ronis, M.J.J., Clarkson, T.B., Wilson, M.E. &Badger, T.M. (2006). Metabolic phenotype <strong>of</strong> is<strong>of</strong>lavones differ among females rats,pigs, monkeys, and women. Journal <strong>of</strong> Nutrition, Vol. 136, No. 5, (May 2006), pp.1215–1221, ISSN 0022-3166.Guerrero, J.A., Lozano, M.L., Castillo, J., Benavente-García, O., Vicente, V. & Rivera, J.(2005). Flavonoids inhibit platelet function through binding to the thromboxane A2receptor. Journal <strong>of</strong> Thrombosis and Haemostasis, Vol. 3, No. 2, (February 2005), pp.369-376, ISSN 1538-7933.Hasler, C.M. & Kundrat, S. (2002). Soy is<strong>of</strong>lavones as functional ingredients in women’shealth. G.S. Gilani & J.J.B. Anderson (eds). Phytoestrogens and Health. AOCS Press,pp. 32-50, ISBN 1893997324, USA.Hooper, L., Ryder, J.J., Kurzer, M.S., Lampe, J.W., Messina, M.J., Phipps, W.R. & Cassidy, A.(2009). Effects <strong>of</strong> soy protein and is<strong>of</strong>lavones on circulating hormone concentrationsin pre- and post-menopausal women: a systematic review and meta-analysis.Human Reproduction Update, Vol.15, No.4, (April 2009), pp. 423–440, ISSN 1460-2369.Hsu, B-Y., Inbaraj, B.S. & Chen, B-H. (2010). Analysis <strong>of</strong> soy is<strong>of</strong>lavones in foods andbiological fluids: an overview. Journal <strong>of</strong> Food and Drug Analysis, Vol. 18, No. 3,(March 2010), pp. 141-154, ISSN 1021-9498.Hu, M. (2007). Commentary: Bioavailability <strong>of</strong> flavonoids and polyphenols: call to arms.Molecular Pharmaceutics, Vol. 4, No. 6, (December 2007), pp. 803–806, ISSN 1543-8384.Huang, J.S., Ramamurthy, S.K., Lin, X. & Le Breton, G.C. (2004). Cell signalling throughthromboxane A2 receptors. Cell Signaling, Vol. 16, No. 5, May 2004), pp. 521-533,ISSN 1945-0877.Huang, Y., Cao, S., Nagamani, M., Anderson, K.E., Grady, J.J. & Lu, L.J.W. (2005). Decreasedcirculating levels <strong>of</strong> tumor necrosis factor-alpha in postmenopausal women duringconsumption <strong>of</strong> soy-containing is<strong>of</strong>lavones. Journal <strong>of</strong> Clinical Endocrinology andMetabolism, Vol. 90, No. 7, (July 2005), pp. 3956-3962, ISSN 0021-972X.Hwang, T.C., Smith, A.L., Konig, P., Clarke, L.L., Price, E.M. & Cohn, L.A. (1999). Genisteinfor the treatment <strong>of</strong> cystic fibrosis. US patent 5,948,814. September 7.
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PrefaceWorldwide, soybean seed prot
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20Soybean and HealthWagner, J.D., A
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22Soybean and HealthDifferences in
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24Soybean and Healthfermented chung
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26Soybean and HealthIsoflavones, wh
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30Soybean and Health5. Metabolite p
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32Soybean and Healththat various me
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34Soybean and Healtheffects on hypo
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40Soybean and Healththe N-terminus
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42Soybean and HealthYAVE, IVAE, LVA
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44Soybean and Healthrespectively, w
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46Soybean and HealthIn order to des
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48Soybean and Healthpeptides that w
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52Soybean and HealthGibbs, B.F.; Zo
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78Soybean and HealthMalaisse, W.J.
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80Soybean and Healthflavonoids show
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84Soybean and Healthal., 2004). For
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The Effect of Flavonoids in Soybean
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Effects of Dietary Soybean Trypsin
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Conjugated Linoleic Acid: A Milk Fa
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Lunasin, a Cancer Preventive Seed P
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9Occurrence of Biogenic Aminesin So
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10Biologically Active Molecules fro
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11From Soybean Phytosterolsto Stero
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12Genistein Derivatization - From a
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13Soybean Oil: Production Process,
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18Antioxidant and Hypocholesterolem
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19Important Minor Soybens Proteins:
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20Soybean Allergens: Presence, Dete
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21Nutritional and Bioactive Compoun
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22Polyamines - The Principal Candid
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