354Soybean and HealthNorth American Menopause Society (2000). The role <strong>of</strong> is<strong>of</strong>lavones in menopausal health:Consensus Opinion <strong>of</strong> the North American Menopause Society. Menopause, Vol. 7,No. 4, (July-August 2000), pp. 215–229, ISSN 1072-3714.North American Menopause Society (2006). Management <strong>of</strong> osteoporosis inpostmenopausal women: 2006 position statement <strong>of</strong> the North AmericanMenopause Society. Menopause, Vol.13, No. 3, (June 2006), pp. 340-367, ISSN 1072-3714.North American Menopause Society (2010). Management <strong>of</strong> osteoporosis inpostmenopausal women: 2010 position statement <strong>of</strong> The North AmericanMenopause Society. Menopause, Vol. 17, No. 1, (January 2010), pp. 25-54, ISSN 1072-3714.Nurmi, T., Mazur, W., Heionen, S., Kokkonen, J. & Adlercreutz, H. (2002). Is<strong>of</strong>lavonecontent <strong>of</strong> the soy based supplements. Journal <strong>of</strong> Parrmaceutical and BiomedicalAnalysis, Vol. 28, No. 1, (April 2002), pp. 1-11, ISSN 0731-7085.Ohta, A., Uehara, M., Sakai, K., Takasaki, M., Adlercreutz, H., Morohashi, T. & Ishimi, Y.(2002). A combination <strong>of</strong> dietary fructooligosaccharides and is<strong>of</strong>lavone conjugatesincreases femoral bone mineral density and equol production in ovariectomizedmice. Journal <strong>of</strong> Nutrition, Vol. 132, No. 7, (July 2002), pp. 2048-2054, ISSN 0022-3166.Ørgaard A, Jensen L (2008). The effects <strong>of</strong> soy is<strong>of</strong>lavones on obesity. Experimental Biologyand Medicine (Maywood), Vol. 233, No. 9, (September 2008), pp. 1066–1080, ISSN0022-3166.Park, S.A., Choi, M-S., Cho, S-Y., Seo, J-S., Jung, U.J., Kim, M-J., Sung, M-K., Park, Y.B. &Lee, M-K. (2006). Genistein and daidzein modulate hepatic glucose and lipidregulating enzyme activities in C57BL/KsJ-db/db mice. Life Sciences, Vol. 79, No. 12,(August 15, 2006), pp. 1207-1233, ISSN 0024-3205.Park, C.E., Yun, H., Lee, E-B., Min, B-I., Bae, H., Choe, W., Kang, I., Kim, S-S. & Ha, J. (2010).The antioxidant effects <strong>of</strong> genistein are associated with AMP-activated proteinkinase activation and PTEN induction in prostate cancer cells. Journal <strong>of</strong> MedicinalFood , Vol. 13, No. 4, (August 2010), pp. 815–820, ISSN 1096-620X.Petrakis, N. L., Barnes, S., King, E. B., Lowenstein, J., Wiencke, J., Lee, M. N., Miike, R., Kirk,M. & Coward, L. (1996). Stimulatory influence <strong>of</strong> soy protein isolate on breast fluidsecretion in pre- and postmenopausal women. Cancer Epidemiology, Biomarkers, andPrevention, Vol. 5, No., (October 1996), pp. 785–794, ISSN 1055-9965.Potter, S.M., Baum, J.A., Teng, H., Stillman, R.J., Shay, N.F. & Erdman, J.W. Jr. (1998). Soyprotein and is<strong>of</strong>lavones: Their effect on blood lipids and bone density inpostmenopausal women. American Journal <strong>of</strong> Clinical Nutrition, Vol. 68, No. 6 (supplDecember 1998), pp.1375S–1379S, ISSN 0002-9165.Potter, S.M., Henley, E.C. & Waggle, D.H. (1999). Method for decreasing LDL-cholesterolconcentration and increasing HDL-cholesterol concentration in the blood to reducethe risk <strong>of</strong> atherosclerosis and vascular disease. US patent 5,855,892. January 5.Prasain, J.K., Xu, J., Kirk, M., Smith Johnson, M., Sfakianos, J. & Barnes, S. (2006). Differentialbiliary excretion <strong>of</strong> genistein metabolites following intraduodenal and intravenousinfusion <strong>of</strong> genistin in female rats. Journal <strong>of</strong> Nutrition, Vol. 136, No. 12, (December2006), pp. 2975–2979, ISSN 0022-3166.
Soy Is<strong>of</strong>lavones as Bioactive Ingredients <strong>of</strong> Functional Foods 355Raju, J., Bielecki, A., Caldwell, D., Lok, E., Taylor, M., Kapal, K., Curran, I., Cooke, G.M.,Bird, R.P. & Mehta, R. (2009). Soy is<strong>of</strong>lavones modulate azoxymethane-induced ratcolon carcinogenesis exposed pre- and postnatally and inhibit growth <strong>of</strong> DLD-1human colon adenocarcinoma cells by increasing the expression <strong>of</strong> estrogenreceptor-beta. Journal <strong>of</strong> Nutrition, Vol. 139, No. 3, (March 2009), pp. 474–481, ISSN0022-3166.Rassi, C.M., Lieberherr, M., Chaumaz, G., Pointillart, A. & Cournot, G. (2002). Downregulation<strong>of</strong> osteoclast differentiation by daidzein via caspase 3. Journal <strong>of</strong> Bone andMineral Research, Vol. 17, No. 4, (April 2002), pp. 630 -638, ISSN 0884-0431.Reinwald, S., Akabas, S.R., & Weaver, C.M. (2010). Whole versus the piecemeal approach toevaluating soy. Journal <strong>of</strong> Nutrition, Vol. 140, No. 12, (December 2010), pp. 2335S–2343S, ISSN 0022-3166.Richelle. M., Pridmore-Merten, S., Bodenstab, S., Enslen, M. & Offord, E.A. (2002).Hydrolysis <strong>of</strong> is<strong>of</strong>lavone glycosides to aglycones by -glycosidase does not alterplasma and urine is<strong>of</strong>lavone pharmacokinetics in postmenopausal women. Journal<strong>of</strong> Nutrition, Vol. 132, No. 9, (September 2002), pp. 2587–2592, ISSN 0022-3166.Rozman, K.K., Bhatia, J., Calafat, A.M., Chambers, C., Culty, M., Etzel, R.A., Marty, S.,Hansen, D.K., Flaws, J.A., Chambers, C., Thomas, J.A., Hoyer, P.B. & Umbach, D.(2006). NTP-CERHR expert panel report on the reproductive and developmentaltoxicity <strong>of</strong> genistein. Birth Defects Research (Part B), Vol. 77, No. 6, (December 2006),pp. 485-638, ISSN 1542-9741.Rüfer, C.E. & Kulling, E. (2006). Antioxidant activity <strong>of</strong> is<strong>of</strong>lavones and their majormetabolites using different in vitro assays. Journal <strong>of</strong> Agricultural and Food Chemistry,Vol. 54, No. 8, (March 2006), pp. 2926-2931, ISSN 0021-8561.Ruiz-Larrea, M.B., Mohan, A.R., Paganga, G., Miller N.J., Bolwell, G.P. & Rice-Evans, C.A.(1997). Antioxidant activity <strong>of</strong> phytoestrogenic is<strong>of</strong>lavones. Free Radical Research,Vol. 26, No. 1, (January 1997), pp. 63-70, ISSN 1071-5762.Russo, J. & Russo, I.H. (2006). The role <strong>of</strong> estrogen in the initiation <strong>of</strong> breast cancer. Journal <strong>of</strong>Steroid Biochemistry and Molecular Biology, Vol. 102, No. 1-5, (December 2006), pp.89–96, ISSN 0960-0760.Sacks, F.M., Svetkey, L.P., Vollmer, W.M., Appel, L.J., Bray, G.A., Harsha, D., Obarzanek, E.,Conlin, P.R., Miller 3 rd , E.R., Simons-Morton, D.G., Karanja, N. & Lin, P.H. (2001).DASH-Sodium Collaborative Research Group. Effects on blood pressure <strong>of</strong> reduceddietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet.DASH Sodium Collaborative Research Group. New England Journal <strong>of</strong> Medicine, Vol.344, No. 1, (January 2001), pp. 3–10, ISSN 0028-4793.Sargeant, P., Farndale, R.W. & Sage, S.O. (1993). ADP-and Thapsigargin-evoked Ca2+ entryand protein-tyrosine phosphorylation are inhibited by the tyrosine kinaseinhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded humanplatelets. Journal <strong>of</strong> Biological Chemistry, Vol. 268, No. 24, (August 1993), pp. 18151-18156, ISSN 0021-9258.Sarkar, F.H. & Li, Y. (2002). Mechanisms <strong>of</strong> cancer chemoprevention by soy is<strong>of</strong>lavonegenistein. Cancer and Metastasis Reviews, Vol. 21, No. 3-4, (December 2002), pp. 265–280, ISSN 0167-7659.
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PrefaceWorldwide, soybean seed prot
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20Soybean and HealthWagner, J.D., A
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24Soybean and Healthfermented chung
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26Soybean and HealthIsoflavones, wh
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30Soybean and Health5. Metabolite p
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32Soybean and Healththat various me
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42Soybean and HealthYAVE, IVAE, LVA
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44Soybean and Healthrespectively, w
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Effects of Dietary Soybean Trypsin
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Conjugated Linoleic Acid: A Milk Fa
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9Occurrence of Biogenic Aminesin So
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10Biologically Active Molecules fro
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11From Soybean Phytosterolsto Stero
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12Genistein Derivatization - From a
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13Soybean Oil: Production Process,
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18Antioxidant and Hypocholesterolem
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19Important Minor Soybens Proteins:
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20Soybean Allergens: Presence, Dete
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21Nutritional and Bioactive Compoun
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22Polyamines - The Principal Candid
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