356Soybean and HealthScalbert, A. & Williamson, G. (2000). Dietary intake and bioavailability <strong>of</strong> polyphenols.Journal <strong>of</strong> Nutrition, Vol. 130, No. 8, (August 2000), pp. 2073S–2085S, ISSN 0022-3166.Scheiber, M.D., Liu, J.H., Subbiah, M.T., Rebar, R.W. & Setchell, K.D.R. (2001). Dietaryinclusion <strong>of</strong> whole soy foods results in significant reductions in clinical riskfactors for osteoporosis and cardiovascular disease in normal postmenopausalwomen. Menopause, Vol. 8, No.5, (September-October 2001), pp.384–392, ISSN1072-3714.Segelman, A.B. (2000). Use <strong>of</strong> is<strong>of</strong>lavones to prevent hair loss and preserve the integrity <strong>of</strong>existing hair. US patent 6,017,893. January 25.Setchell, K.D.R. & Cassidy, A. (1999). Dietary is<strong>of</strong>lavones: biological effects and relevance tohuman health. Journal <strong>of</strong> Nutrition, Vol. 129, No. 3, (March 1999), pp. 758S-767S,ISSN 0022-3166.Setchell, K.D.R., Brown, N.M., Desai, P., Zimmer-Nechemias, L., Wolfe, B.E., Brashear, W.T.,Kirschner, A.S., Cassidy, A. & Heubi, J.E. (2001). Bioavailability <strong>of</strong> pure is<strong>of</strong>lavonesin healthy humans and analysis <strong>of</strong> commercial soy is<strong>of</strong>lavone supplements. Journal<strong>of</strong> Nutrition, Vol. 131, No. 4, (April 2001), pp. 1362S–1375S, ISSN 0022-3166.Setchell, K.D.R., Brown, N.M., Zimmer-Nechemias, L., Brashear, W.T., Wolfe, B.E.,Kirschner, A.S. & Heubi, J.E. (2002a). Evidence for lack <strong>of</strong> absorption <strong>of</strong> soyis<strong>of</strong>lavone glycosides in humans, supporting the crucial role <strong>of</strong> intestinalmetabolism for bioavailability. American Journal <strong>of</strong> Clinical Nutrition, Vol. 76, No. 2,(August 2002), pp. 447–453, ISSN 0002-9165.Setchell, K.D.R., Brown, N.M. & Lydeking-Olsen, E. (2002b). The clinical importance <strong>of</strong> themetabolite equol-a clue to the effectiveness <strong>of</strong> soy and its is<strong>of</strong>lavones. Journal <strong>of</strong>Nutrition, Vol.132, No. 12, (December 2002), pp. 3577-3584, ISSN 0022-3166.Setchell, K.D.R., Faughnan, M. S., Avades, T., Zimmer-Nechemias, L., Brown, N. B., Wolfe,B., Brashear, W. T., Desai, P., Oldfield, M. F., Botting, N. P. & Cassidy, A. (2003a).Comparing the pharmacokinetics <strong>of</strong> daidzein and genistein using [13C]labeledtracers in premenopausal women. American Journal <strong>of</strong> Clinical Nutrition, Vol. 77,No.2, (February 2003), pp.411-419, ISSN 0002-9165.Setchell, K.D.R., Brown, N.M., Desai, P.B., Zimmer-Nechimias, L., Wolfe, B., Jakate, A.S.,Creutzinger, V. & Heubi, J.E. (2003b). Bioavailability, disposition, and doseresponseeffects <strong>of</strong> soy is<strong>of</strong>lavones when consumed by healthy women atphysiologically typical dietary intakes. Journal <strong>of</strong> Nutrition, Vol. 133, No. 4, (April2003), pp. 1027-1035, ISSN 0022-3166.Setchell, K.D.R. & Lydeking-Olsen, E. (2003). Dietary phytoestrogens and their impact onbone-evidence from in vitro and in vivo, human observational and dietaryintervention studies. American Journal <strong>of</strong> Clinical Nutrition, Vol. 78, No. (supplSeptember 2003), pp. 593S–609S, ISSN 0002-9165.Sfakianos, J., Coward, L., Kirk, M. & Barnes, S. (1997). Intestinal uptake and biliary excretion<strong>of</strong> the is<strong>of</strong>lavone genistein in rats. Journal <strong>of</strong> Nutrition, Vol. 127, No. 7, (July 1997),pp. 1260–1268, ISSN 0022-3166.Shih, H., Pickwell, G.V. & Quattrochi, L.C. (2000). Differential effects <strong>of</strong> flavonoidcompounds on tumor promoter-induced activation <strong>of</strong> the human CYP1A2enhancer. Archives <strong>of</strong> Biochemistry and Biophysics, Vol. 373, No. 1, (January 2000), pp.287–294, ISSN 0003-9861.
Soy Is<strong>of</strong>lavones as Bioactive Ingredients <strong>of</strong> Functional Foods 357Si, H. & Liu, D. (2008). Genistein, a soy phytoestrogen, upregulates the expression <strong>of</strong> humanendothelial nitric oxide synthase and lowers blood pressure in spontaneouslyhypertensive rats. Journal <strong>of</strong> Nutrition, Vol. 138, No. 2, (February 2008), pp. 297-304,ISSN 0022-3166.Singhal, R., Shankar, K., Badger, T.M. & Ronis, M.J. (2009). Hepatic gene expressionfollowing consumption <strong>of</strong> soy protein isolate in female Sprague-Dawley rats differsfrom that produced by 17b-estradiol treatment. Journal <strong>of</strong> Endocrinology, Vol. 202,No. 1, (January 2009), pp. 141–152, ISSN 0022-0795.Slavin, J.L., Karr, S.C., Hutchins, A.M. & Lampe, J.W. (1998). Influence <strong>of</strong> soybeanprocessing, habitual diet, and soy dose on urinary is<strong>of</strong>lavonoid excretion. AmericanJournal <strong>of</strong> Clinical Nutrition, Vol. 68, No. 6 suppl, (December 1998), pp. 1492S–1495S,ISSN 0002-9165.Squadrito, F., Altavilla, E., Crisafulli, A., Saitta, A., Cucinotta, D., Morabito, N., D’Anna, R.,Corrado, F., Ruggeri, P., Frisina, N. & Squadrito, G. (2003). Effect <strong>of</strong> genistein onendothelial function in postmenopausal women: a randomized, double-blind,controlled study. American Journal <strong>of</strong> Medicine, Vol. 114, No. 6, (April 2003), pp. 470-476, ISSN 0002-9343.Somekawa, Y., Chiguchi, M., Ishibashi, T. & Aso, T. (2001). Soy intake related to menopausalsymptoms, serum lipids, and bone mineral density in postmenopausal Japanesewomen. Obstetrics and Gynecology, Vol. 97, No. 1, (January 1997), pp. 109–115, ISSN0029-7844.Song, W.O., Chun, O.K., Hwang, I., Shin, H.S., Kim, B-G., Kim, K.S., Lee, S-L., Shin, D. &Lee, S.G. (2007). Soy is<strong>of</strong>lavones as safe functional ingredients. Journal <strong>of</strong> MedicinalFood, Vol. 10, No. 4, (December 2007), pp. 571-580, ISSN 1096-620XSpector, D., Anthony, M., Alexander, D. & Arab, L. (2003). Soy consumption and colorectalcancer. Nutrition and Cancer, Vol. 47, No. 1, (January 2003), pp. 1–12, ISSN 0163-5581.Stevenson, D.E. & Hurst, R.D. (2007). Polyphenolic phytochemicals – just antioxidants ormuch more? Cellular and Molecular Life Sciences, Vol. 64, No. 22, (November 2007),pp. 2900-2916, ISSN 1420-682X.Stürtz, M., Lander, V., Schmid, W., & Winterhalter, P. (2008). Quantitative determination <strong>of</strong>is<strong>of</strong>lavones in soy based nutritional supplements by high performance liquidchromatography. Journal für Verbraucherschutz und Lebensmittelsicherheit, Vol. 3, No.2, (August 2008), pp. 127–136, ISSN 1661-5751.Sung, H.Y. & Choi, Y.S. (2008). Dose-response assessment <strong>of</strong> the anti-cancer efficacy <strong>of</strong> soyis<strong>of</strong>lavones in dimethylhydrazine-treated rats fed 6% fructooligosaccharide.Nutrition Research and Practice, Vol. 2, No. 2, (Summer issue), pp. 55-61, ISSN 1976-1457.Tamura, A., Shiomi, T., Hachiya, S., Shigematsu, N. & Hara, H., (2008). Low activities <strong>of</strong>intestinal lactase suppress the early phase absorption <strong>of</strong> soy is<strong>of</strong>lavones in Japaneseadults. Clinical Nutrition, Vol. 27, No. 2, (April 2008), pp. 248–253, ISSN 0261-5614.Taylor, C.K., Levy, R.M., Elliott, J.C. & Burnett, B.P. (2009). The effect <strong>of</strong> genistein aglyconeon cancer and cancer risk: a review <strong>of</strong> in vitro, preclinical, and clinical studies.Nutrition Reviews, Vol. 67, No. 7, (July 2009), pp. 398-415, ISSN 0029-6643.
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PrefaceWorldwide, soybean seed prot
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Soybean Products Consumption in the
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20Soybean and HealthWagner, J.D., A
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22Soybean and HealthDifferences in
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24Soybean and Healthfermented chung
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26Soybean and HealthIsoflavones, wh
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28Soybean and HealthThe concentrati
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30Soybean and Health5. Metabolite p
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32Soybean and Healththat various me
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34Soybean and Healtheffects on hypo
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36Soybean and Healthfatty acid oxid
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40Soybean and Healththe N-terminus
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42Soybean and HealthYAVE, IVAE, LVA
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44Soybean and Healthrespectively, w
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46Soybean and HealthIn order to des
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48Soybean and Healthpeptides that w
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52Soybean and HealthGibbs, B.F.; Zo
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80Soybean and Healthflavonoids show
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Effects of Dietary Soybean Trypsin
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Conjugated Linoleic Acid: A Milk Fa
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9Occurrence of Biogenic Aminesin So
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10Biologically Active Molecules fro
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11From Soybean Phytosterolsto Stero
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12Genistein Derivatization - From a
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13Soybean Oil: Production Process,
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18Antioxidant and Hypocholesterolem
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19Important Minor Soybens Proteins:
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20Soybean Allergens: Presence, Dete
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21Nutritional and Bioactive Compoun
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22Polyamines - The Principal Candid
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