352Soybean and HealthLu, L.J. & Anderson, K. E. (1998). Sex and long-term soy diets affect the metabolism andexcretion <strong>of</strong> soy is<strong>of</strong>lavones in humans. American Journal <strong>of</strong> Clinical Nutrition, Vol.68, No. 6, (December 1998), pp. 1500S-1504S, ISSN 0002-9165.Lydeking-Olsen, E., Beck-Jensen, J.E., Setchell, K.D.R. & Holm-Jensen, T. (2004). Soymilk orprogesterone for prevention <strong>of</strong> bone loss-a 2 year randomized, placebo-controlledtrial. European Journal <strong>of</strong> Nutrition, Vol. 43, No. 4, (August 2004), pp. 246-257, ISSN1436-6207.Ma, Y., Sullivan, J.C. & Schreih<strong>of</strong>er, D.A. (2010). Dietary genistein and equol (4′, 7is<strong>of</strong>lavandiol) reduce oxidative stress and protect rats against focal cerebralischemia. American Journal <strong>of</strong> Physiology – Regulatory, Integrative and ComparativePhysiology, Vol. 299, No. 3, (September 2010), pp. R871-R877, ISSN 0363-6119.MacDonald, R.S., Guo, J-Y., Copeland, J., Browning, J.D., Sleper, D., Rottinghaus, G.E. &Berhow, M.A. (2005). Environmental influences on is<strong>of</strong>lavones and saponins insoybeans and their role in colon cancer. Journal <strong>of</strong> Nutrition, Vol. 135, No. 5, (May2005), pp. 1239–1242, ISSN 0022-3166.Mahn, K., Borras, C., Knock, G.A., Taylor, P., Khan, I.Y., Sugden, D., Poston, L., Ward, J.P.,Sharpe, R.M., Vina, J., Aaronson, P.I. & Mann, G.E. (2005). Dietary soy is<strong>of</strong>lavoneinduced increases in antioxidant and eNOS gene expression lead to improvedendothelial function and reduced blood pressure in vivo. FASEB Journal, Vol. 19,No. 12, (October 1, 2005), pp. 1755-1757, ISSN 0892-6638.Manach, C., Scalbert, A., Morand, C., Rémésy, C. & Jiménez, L. (2004). Polyphenols: foodsources and bioavailability. American Journal <strong>of</strong> Clinical Nutrition, Vol. 79, No. 5,(May 2004), pp. 727–747, ISSN 0002-9165.Mann, G.E., Rowlands, D.J., Li, F.Y., de Winter, P. & Siow, R.C. (2007). Activation <strong>of</strong>endothelial nitric oxide synthase by dietary is<strong>of</strong>lavones: role <strong>of</strong> NO in Nrf2-mediated antioxidant gene expression. Cardiovascular Research, Vol. 75, No. 2, (July15, 2007), pp. 261-274, ISSN 0008-6363.Marini, H., Minutoli, L., Polito, F., Bitto, A., Altavilla, D., Atteritano, M., Gaudio, A.,Mazzaferro, S., Frisina, A., Frisina, N., Lubrano, C., Bonaiuto, M., D’Anna, R.,Cannata, M.L., Corrado, F., Adamo, E.B., Wilson, S. & Squadrito, F. (2007). Effects<strong>of</strong> the phytoestrogens genistein on bone metabolism in osteopenic postmenopausalwomen: a randomized trial. Annals <strong>of</strong> Internal Medicine, Vol. 146, No. 12, (June2007), pp. 839-847, ISSN 0003-4819.Martin, D., Song, J., Mark, C. & Eyster, K. (2008). Understanding the cardiovascular actions<strong>of</strong> soy is<strong>of</strong>lavones: potential novel targets for antihypertensive drug development.Cardiovascular & Hematological Disorders-Drug Targets, Vol. 8, No. 4 (December2008), pp. 297-312, ISSN 1871-529X.McClain, R.M., Wolzm, E., Davidovich, A., Pfannkuch, F., Edwards, J.A. & Bausch, J. (2006).Acute, subchronic and chronic safety studies with genistein in rats. Food andChemical Toxicology, Vol. 44, No. 1, (January 2006), pp. 56-80, ISSN 0278-6915.Mei, J., Yeung, S.S. & Kung, A.W. (2001) High dietary phytoestrogen intake is associatedwith higher bone mineral density in postmenopausal but not premenopausalwomen. Journal <strong>of</strong> Clinical Endocrinology and Metabolism, Vol. 86, No. 11, (November2001), pp.5217–5221, ISSN 0021-972X.
Soy Is<strong>of</strong>lavones as Bioactive Ingredients <strong>of</strong> Functional Foods 353Messina, M. & Wu, A.H. (2009). Perspectives on the soy–breast cancer relation. AmericanJournal <strong>of</strong> Clinical Nutrition, Vol. 89, No. 5, (May 2009), pp. 1673S-1679S, ISSN 0002-9165.Messina, M. (2010a). A brief historical overview <strong>of</strong> the past two decades <strong>of</strong> soy andis<strong>of</strong>lavone research. Journal <strong>of</strong> Nutrition, Vol. 140, No. 7, (July 2010), pp. 1350S–1354S, ISSN 0022-3166.Messina, M. (2010b). Insights gained from 20 years <strong>of</strong> soy research. American Journal <strong>of</strong>Clinical Nutrition, Vol. 140, No. 12, (December 2010), pp. 2289S-2295S, ISSN 0002-9165.Moon, Y.J., Wang, X. & Morris, M.E. (2006). Dietary flavonoids: Effects on xenobiotic andcarcinogen metabolism. Toxicology in Vitro, Vol. 20, No. 2, (March 2006), pp. 187–210, ISSN 0887-2333.Munoz, Y., Garrido, A. & Valladares, L. (2009). Equol is more active than soy is<strong>of</strong>lavoneitself to compete for binding to thromboxane A(2) receptor in human platelets.Thrombosis Research, Vol. 123, No. 5, (March 2009), pp. 740-744, ISSN 0049-3848.Murota, K., Shimizu, S., Miyamoto, S., Izumi, T., Obata, A., Kikuchi, M., & Terao, J. (2002).Unique uptake and transport <strong>of</strong> is<strong>of</strong>lavone aglycones by human intestinal Caco-2cells: Comparison <strong>of</strong> is<strong>of</strong>lavones and flavonoids. Journal <strong>of</strong> Nutrition, Vol. 132, No. 7,(July 2002), pp. 1956–1961, ISSN 0022-3166.Naaz, A., Yellayi, S., Zakroczymski, M.A., Bunick, D., Doerge, D.R., Lubahn, D.B., Helferich,W.G. & Cooke, P.S. (2003). The soy is<strong>of</strong>lavone genistein decreases adiposedeposition in mice. Endocrinology, Vol. 144, No. 8, (August 2003), pp. 3315-3320,ISSN 0013-7227.Naciff, J.M., Hess, K.A., Overmann, G.J., Torontali, S.M., Carr, G.J., Tiesman, J.P., Foertsch,L.M., Richardson, B.D., Martinez, J.E. & Daston, G.P. (2005). Gene expressionchanges induced in the testis by transplacental exposure to high and low doses <strong>of</strong>17a-ethynyl estradiol, genistein, or bisphenol A. Toxicological Sciences, Vol. 86, No. 2,(August 2005), pp. 396–416, ISSN 1096-6080.Nagata, C., Iwasa, S., Shiraki, M., Ueno, T., Uchiyama, S., Urata, K., Sahashi, Y. &Shimizu, H. (2006). Associations among maternal soy intake, is<strong>of</strong>lavone levels inurine and blood samples, and maternal and umbilical hormone concentrations(Japan). Cancer Causes and Control, Vol. 17, No. 9, (November 2006), pp. 1107–1113, ISSN 0957-5243.Nakashima, S., Koike, T. & Nozawa, Y. (1991). Genistein, a protein tyrosine kinase inhibitor,inhibits thromboxane A2-mediated human platelet responses. MolecularPharmacology, Vol. 39, No. 4, (April 1991), pp. 475-480, ISSN 0026-895X.Nestel, P.J., Yamashita, T., Sasahara, T., Pomeroy, S., Dart, A., Komesar<strong>of</strong>f, P., Owen, A. &Abbey, M. (1997). Soy is<strong>of</strong>lavones improve systemic arterial compliance but notplasma lipids in menopausal and perimenopausal women. Arteriosclerosis,Thrombosis, and Vascular Biology, Vol. 17, No. 12, (December 1997), pp. 3392-3398,ISSN 10795642.Nielsen, I.L.F. & Williamson, G. (2007). Review <strong>of</strong> the factors affecting bioavailability <strong>of</strong> soyis<strong>of</strong>lavones in humans. Nutrition and Cancer, Vol. 57, No. 1, pp. 1-10, ISSN 0163-5581.
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PrefaceWorldwide, soybean seed prot
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Soybean Products Consumption in the
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20Soybean and HealthWagner, J.D., A
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22Soybean and HealthDifferences in
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24Soybean and Healthfermented chung
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26Soybean and HealthIsoflavones, wh
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28Soybean and HealthThe concentrati
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30Soybean and Health5. Metabolite p
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32Soybean and Healththat various me
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34Soybean and Healtheffects on hypo
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40Soybean and Healththe N-terminus
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42Soybean and HealthYAVE, IVAE, LVA
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44Soybean and Healthrespectively, w
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46Soybean and HealthIn order to des
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48Soybean and Healthpeptides that w
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64Soybean and Healthmeasured in eac
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80Soybean and Healthflavonoids show
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The Effect of Flavonoids in Soybean
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Effects of Dietary Soybean Trypsin
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Conjugated Linoleic Acid: A Milk Fa
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9Occurrence of Biogenic Aminesin So
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10Biologically Active Molecules fro
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11From Soybean Phytosterolsto Stero
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12Genistein Derivatization - From a
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13Soybean Oil: Production Process,
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18Antioxidant and Hypocholesterolem
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19Important Minor Soybens Proteins:
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20Soybean Allergens: Presence, Dete
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21Nutritional and Bioactive Compoun
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22Polyamines - The Principal Candid
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