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Chapter 5. MECHANOBIOLOGY<br />

..... .111 lLE _IMI!'~ •<br />

Mechanobiology is a branch of biophysics that studies the<br />

effects of external mechanical factors on living organisms and<br />

their ability to respond to these factors (to provide mechanoreception).<br />

5.1. MECHANORECEPTION<br />

Mechanoreceptors are specialized sensory formations which<br />

convert mechanical stimuli into the activity of neural cells. The<br />

mechanoreceptors can respond to different mechanical stimuli<br />

such as tactile sensitivity (response to touch, pressure, and vibration),<br />

vestibuloreception (control of equilibrium), and proprioception<br />

(coordination of the relative positions of various parts<br />

of the body).<br />

5.1.1. Tactile Sensitivity<br />

Vision. The human eye has at most 200,000 cones per square millimeter.<br />

Hawks, who must spot small prey from the sky, possess about five<br />

times as many as humans; they can see details at distance two or three<br />

times farther than humans<br />

There are a number of mechanoreceptors in the skin: free<br />

ending of afferent fibers, Meissner's corpuscles, Pacinian corpuscles,<br />

Merkel's disks, Krause's end-bulbs, and Ruffini corpuscles. Many<br />

vertebrates also use specialized hairs, vibrissae, such as those<br />

around a seal's muzzle or car's whiskers, which heighten the<br />

sense of touch. Vibrissae bend in contact with a solid object.<br />

Usually mechanoreceptors induce a change in the ion permeability<br />

of receptor cell membranes inducing an electrical signal, the<br />

receptor potential, which is transmitted to the brain. An example<br />

of mechanoreceptors is depicted in fig. 5.1.<br />

5.1.2. The Vestibular System<br />

Vestibuloreception is the response to a change in rotary acceleration<br />

and deceleration and the direction of displacement in<br />

space. Such a response is used by humans and other animals to<br />

control their body posture and locomotion. The vestibular system<br />

is located in the inner ear, or labyrinth, and consists of three<br />

semicircular canals located at right angles to each other and<br />

a pair of saclike structures called the utricle and saccule (fig. 5.2).<br />

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