Download Booklet - Diabetes in Asia Study Group
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Abstract Title<br />
Roll of cytok<strong>in</strong>es <strong>in</strong> diabetic heart failure<br />
Prof. Shamima Parv<strong>in</strong> Lasker<br />
M sc, M phil, phD fellow<br />
abstract: heart failure is the major cause of death <strong>in</strong> patients with diabetes. risk of death is<br />
<strong>in</strong>creased many fold if diabetes is associated with coronary artery disease (CaD). a number of<br />
experimental studies have been carried out to determ<strong>in</strong>e what structural alteration deteriorates<br />
the cardiac function <strong>in</strong> drug <strong>in</strong>duced diabetic animals but the biomolecular mechanisms responsible<br />
for heart failure from diabetes still rema<strong>in</strong> unclear. no study has yet been undertaken to correlate<br />
between diabetes and myocyte disarray. it has been suggested that collagenolytic enzymes<br />
collectively known as matrix metalloprote<strong>in</strong>ase (MMps) become activated with<strong>in</strong> the fail<strong>in</strong>g<br />
heart. Conceptually, activation of MMps might be expected to lead to progressive degradation<br />
of the extracellular matrix, which <strong>in</strong> turn leads to slippage of the myocyte bundle with<strong>in</strong> the left<br />
ventricular wall caus<strong>in</strong>g heart failure. tissue necrosis factor, cytok<strong>in</strong>es and peptide growth factors<br />
expressed with<strong>in</strong> the fail<strong>in</strong>g myocardium are capable of activat<strong>in</strong>g MMps.<br />
theoretically <strong>in</strong>creased levels of cytok<strong>in</strong>es may <strong>in</strong>duce a greater quantity of myocardial cell<br />
slippage. therefore there relationship may exist between the activity of cytok<strong>in</strong>es and myocyte<br />
disarray <strong>in</strong> diabetes heart failure.<br />
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