Download Booklet - Diabetes in Asia Study Group

Abstract Title
Nanotechnology-Based Management of Diabetes Mellitus
Hosiny Hamed
Nanotechnology is an emerging branch of science for designing tools and devices of size 1 to 100
nanometers with unique function at the cellular, atomic and molecular levels. Nanoparticles
possess some novel properties not seen with the macro molecules. Nanotechnology has
applications in practically every branch of medicine including the field of diabetes.
Nanosensors for Glucose Monitoring
Deployment of nanoparticles in the dermis may allow transdermal monitoring of glucose changes
in interstitial fluid. noninvasive glucose sensing will maximize acceptance by patients and overcome
biocompatibility problems of implants. researchers have fabricated and tested a novel biosensor
that detects glucose close to real time and with much greater sensitivity than other comparable,
biocompatible sensors.
Nanotechnology-Based Methods for Delivery of Antidiabetic Agents
the development and clinical introduction of better delivery methods, both for insulin and also
for the newly developed incretin agents, is needed. nanotechnology should also improve on this
by developing noninjectable forms of drug-carrying nanoparticles capable of feedback-modulated
release of therapeutic agents to control glucose homeostasis according to the current physiological
needs of the patient.
Nanotechnology-Based Device for Insulin Delivery
a possible nanoscale device with channels and insulin monomers/dimers enclosed has been
proposed that will sense the increase in glucose levels and release monomeric insulin through
channels in the nanocapsule. upon return of glucose levels to basal levels, the channels will close
and insulin passage is stopped
Nanoparticle Insulin Formulations for Spray Inhalation
scientists are working on new nanoparticle drug formulations to improve the effectiveness of
insulin taken through spray inhalers. the team’s approach is to prepare the drug in nanoparticle
form, ensuring the correct dosage reaches the lung and the drug retains its stability, and providing
the possibility of slowing the release of the drug in the lung for longer therapeutic effect. initial
studies suggest insulin is absorbed three to four times more effectively by this process.
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