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Abstract Title THE LEGACY OF HYPERGLYCEMIC MEMORY IS ASSOCIATED WITH EPIGENETIC CHANGES Assam El-Osta Vascular complications occur as a result of pathological processes, which are activated by chronic hyperglycemia. It is know clearly evident that metabolic memory, whereby diabetic complications continue to develop and progress even in individuals who have returned to improved glycemic control could have long lasting effects. The Diabetes Control Complications Trial (DCCT) and The Epidemiology of Diabetes Interventions and Complications Study (EDIC) outcome data demonstrate that despite similar levels of glycemic control, those individuals in the original intensive therapy group continue to have reduced rates of complications development despite having similar levels of glycemic control. Collectively, these observations support the concept that an earlier period of hyperglycemia can lead to subsequent sustained and long lasting effects within the vasculature, ultimately resulting in ongoing organ injury and dysfunction. This recognized phenomenon of hyperglycemic memory is perhaps the most clinically important and unsolved problem in diabetes research (1). Here we show that ambient or prior hyperglycemia induces specific epigenetic changes associated with histone methylase and demethylase enzymes in primary human aortic endothelial cells (2). These results provide a molecular basis for explaining hyperglycemic memory, and, suggest that the concomitant methylation changes on histones may play a more general role in regulating transcriptional activity in diabetes. These studies address a critical gap and add significant new data to advance our understanding of metabolic memory. The results to these experiments are the first installment in determining markedly different transcriptional behaviors and epigenetic changes in diabetes using largescale epigenomic approaches. 56
Abstract Title Predictors of Outcome in Hyperglycemic Crises in Adult Diabetic Patients in Upper Egyptian Locality Lobna El-Toni Mohamed A Tohamy , Lobna F El-Tooney , Mostafa A Haridi and Muhammad Abu El-Maaty, Adel A El-Sayed Background: Diabetic ketoacidosis (DKa) and hypersolar hyperglycemic state (hhs) are the two most serious acute hyperglycemic crises in diabetes even if managed properly. the aim of the study was to identify the predictors of outcome in hyperglycemic crises whether clinical and or laboratory since admission till recovery. in this study 80 diabetic adult patients were included 70 patients with DKa (87.5%) and 10 patients with hhs (12.5%) admitted to the internal Medicine Department, assiut university hospital , egypt during the period of May 2005 to May 2006. the results of the study showed that patients with hhs were significantly older than patients with DKa group. Disturbed level of consciousness was found in all hhs group which carried a bad outcome in both groups of patients . infection was the main precipitating factors in both crises (42.9% in DKa and 70% in hhs) followed by problems in treatment either by using insufficient doses or discontinuation of therapy. patients with hhs had higher admission effective osmolality , higher anion gap and impaired renal function than those with DKa with bad resultant outcome. bad outcome (death) were demonstrated in 4.3% of DKa and 40% of hhs. predictors of outcome in hyperglycemic crises included patients > 50 years , severe coexisting diseases, stress and infections were the major precipitating causes of bad outcome particularly in hhs group. persistent high serum glucose > 300 mg/ dL for 12 hours since admission contributed to bad outcome in both groups. furthermore, persistent (> 24h ) high serum sodium and significant increase in serum osmolality (> 350 mosm/Kg) in hhs group together with severe acidosis (low ph 100 unit of r insulin within 24 hours of admission carried bad outcome in both groups. 57
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Diabetes in asia stuDy Group (DasG)
Page 5 and 6: PreFace First up all I am particula
Page 7 and 8: Future perspective in type 2 Diabet
Page 9 and 10: LiSt of frEE PAPErS Papers and Spea
Page 11 and 12: SPEAKErS 11
Page 13 and 14: Prof. Abdul Basit, F.R.C.P (Lon) Pr
Page 15 and 16: Prof. Noorjahan Samad MBBS, D.R.C.O
Page 17 and 18: Prof. Anoop Presently the director
Page 19 and 20: Prof. Edwin Gale Edwin Gale qualifi
Page 21 and 22: Prof. Muhammad Yakoob Ahmedani Prof
Page 23 and 24: Dr. Arun K Baksi Secretary General
Page 25 and 26: Program Manager Qatar Diabetes Asso
Page 27 and 28: Prof. Abdul Basit Speakers & Topics
Page 29 and 30: with increasing diabetes prevalence
Page 31 and 32: With its tendency to have accelerat
Page 33 and 34: ORGANIZING DIABETES CARE IN A RESOU
Page 35 and 36: Dr.Nabil Isseh Diabetes In the Midd
Page 37 and 38: Patient Education in preventing Hyp
Page 39 and 40: Abstract Title Living with Diabetes
Page 41 and 42: Abstract Title INVENTORY OF DIABETE
Page 43 and 44: Abstract Title Knowledge, Skills an
Page 45 and 46: 2) Medical history of the patients:
Page 47 and 48: nephropathy, followed by peripheral
Page 49 and 50: Abstract Title HiGH BLooD GLuCose a
Page 51 and 52: Abstract Title Prevalence figures f
Page 53 and 54: Abstract Title Final Height Achieve
Page 55: Abstract Title Diabetes Mellitus du
Page 59 and 60: Abstract Title PROJECT KADAM Knowle
Page 61 and 62: Abstract “Diabetes Care for Schoo
Page 63 and 64: 13:30-14:00 14:00-14:30 14:30-15:00
Page 65 and 66: 12:00-13:00 Secondary prevention: W
Page 67 and 68: DASG Journal Journal of Diabetology
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