Antibody Mediated Rejection in Heart Transplantation
Antibody Mediated Rejection in Heart Transplantation
Antibody Mediated Rejection in Heart Transplantation
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Diagnostic Criteria:<br />
<strong>Antibody</strong> <strong>Mediated</strong> <strong>Rejection</strong><br />
• New pathologic diagnostic criteria<br />
pAMR 0: both histological and immunopathological<br />
studies are negative<br />
pAMR 1(H+):suspicious for pathologic AMR<br />
histopathological alone<br />
pAMR 1 (I+): suspicious for pathologic AMR<br />
immunopathological alone<br />
pAMR 2: both histological and immunopathological<br />
studies are positive<br />
pAMR 3: severe AMR; <strong>in</strong>terstitial hemorrahge, capillary<br />
fragmentation, mixed <strong>in</strong>flammatory <strong>in</strong>filtrates, endothelial<br />
cell pyknosis, and /or karyorrhexis, marked edema<br />
• Serologic evidence of donor specific<br />
anti-HLA Ab and non-HLA antibodies<br />
Berry, G et al. J <strong>Heart</strong> Lung Transplant 2011. 30( 6):601-11
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