Antibody Mediated Rejection in Heart Transplantation
Antibody Mediated Rejection in Heart Transplantation
Antibody Mediated Rejection in Heart Transplantation
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Desensitization Protocol:<br />
Manag<strong>in</strong>g Refractory Antibodies<br />
• Some patients have a<br />
persistently elevated<br />
PRA despite<br />
plasmapheresis, IV Ig<br />
and rituximab<br />
Median fluorescent <strong>in</strong>tensity<br />
20000<br />
18000<br />
16000<br />
14000<br />
12000<br />
10000<br />
8000<br />
6000<br />
4000<br />
2000<br />
0<br />
Drop after 1 st<br />
round of PP, IV<br />
Ig, ritux<br />
Rebound after 2 nd<br />
round of IV Ig, ritux<br />
1/4/09 3/3/09 3/26/09 4/22/09<br />
DR7<br />
DQ7<br />
DQ9<br />
B78<br />
B51<br />
Drop after<br />
bortezomib
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