Antibody Mediated Rejection in Heart Transplantation
Antibody Mediated Rejection in Heart Transplantation
Antibody Mediated Rejection in Heart Transplantation
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Proliferation signal <strong>in</strong>hibitors (PSIs)<br />
� Mechanism<br />
l� Inhibit proliferation of T, B,<br />
smooth muscle,<br />
endothelial cells<br />
� In cl<strong>in</strong>ical trials<br />
l� ↓ rejection, CAV<br />
l� ↓ viral <strong>in</strong>fections<br />
l� ↑ renal <strong>in</strong>sufficiency<br />
l� Impaired wound heal<strong>in</strong>g<br />
� Indications for sirolimus/<br />
everolimus<br />
l� <strong>Rejection</strong><br />
l� CAV<br />
l� Malignancy<br />
l� Viral <strong>in</strong>fections (CMV)<br />
l� Renal dysfunction (i/o<br />
CNI)<br />
Incidence of treated rejection<br />
Kobashigawa et al. Am J Transplant 2006;6:1377-86.
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