Antibody Mediated Rejection in Heart Transplantation
Antibody Mediated Rejection in Heart Transplantation
Antibody Mediated Rejection in Heart Transplantation
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Prospective Crossmatch<br />
• Purpose<br />
– Avoid donors with HLA to which<br />
the recipient has cytotoxic anti-<br />
HLA antibodies<br />
– Prevent hyperacute rejection<br />
• Process<br />
– Test recipient serum aga<strong>in</strong>st<br />
donor cells<br />
– Geographic constra<strong>in</strong>ts to limit<br />
the donor pool<br />
• Indications<br />
– Pre-transplant, if multiple<br />
low-level anti-HLA Ab<br />
(MFI 2000-5000)<br />
– Post-transplant surveillance<br />
T CELL FLOW CROSSMATCH POSITIVE "<br />
T CELL MCS 51 "<br />
"<br />
T cell MCS Reference range:"<br />
<strong>Heart</strong> : Negative < 50 MCS <br />
"<br />
B CELL FLOW CROSSMATCH NEGATIVE<br />
B CELL MCS 65 "<br />
"<br />
B cell MCS Reference range: <br />
H e a r t : N e g a t i v e < 1 2 1 M C S "
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