Antibody Mediated Rejection in Heart Transplantation

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Antibody-Mediated Rejection H & E Intravascular cells; no lymphocytes A B I m unoperoxidase C CD68 Prominent macrophages EC;Intravascuar E macrophages F D CD3 Rare T lymphocytes CD34 C4d Complement in capillaries Courtesy Michelle Kittleston from Wu, G et al J Heart Lung Transpl 2009;28:417-22
EC swelling; Macrophages C4D stain Surrounds EC Gonzales-Stawinski GV et al J Heart Lung Transplant 2008;27:375-61
Page 1 and 2: Antibody Mediated Rejection in Hear
Page 3 and 4: Rejection
Page 5 and 6: PERCENTAGE OF ADULT HEART TRANSPLAN
Page 7 and 8: Basic Transplant Immunology Two for
Page 9 and 10: Antithymocyte/antilymphocyte Antith
Page 11 and 12: Right Ventricular Endomyocardial Bi
Page 13 and 14: Grade 2R = MODERATE CR RX! IV stero
Page 15 and 16: Clinical Characteristics of Antibod
Page 17 and 18: Asymptomatic/Subclinical AMR: Incre
Page 19 and 20: Asymptomatic AMR: Lessons Learned
Page 21: Diagnostic Criteria: Antibody Media
Page 25 and 26: Recommended Frequency for Routine M
Page 27 and 28: Challenges of Antibody-Mediated Rej
Page 29 and 30: Assessing Panel Reactive Antibodies
Page 31 and 32: Assessing Panel Reactive Antibodies
Page 33 and 34: What matters clinically: Calculated
Page 35 and 36: What matters clinically: The Calcul
Page 37 and 38: Desensitization Protocols • Adapt
Page 39 and 40: Desensitization Protocol: Managing
Page 41 and 42: Prospective Crossmatch • Purpose
Page 43 and 44: 257 samples from highly sensistized
Page 45 and 46: Challenges of Antibody-Mediated Rej
Page 47 and 48: Cellular Antibody-Mediated Asymptom
Page 49 and 50: Acute therapy determined by clinica
Page 51 and 52: Proliferation signal inhibitors (PS
Page 53 and 54: Photopheresis • Principle - “Im
Page 55 and 56: Clinical Characteristics of Antibod
Page 57 and 58: 25 yr M 3 yrs S/P OHT noncompliant
Page 59 and 60: Antibody-Mediated Rejection: Summar

Antibody Mediated Rejection in Heart Transplantation

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