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Antibody Mediated Rejection in Heart Transplantation

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Acute therapy<br />

determ<strong>in</strong>ed by<br />

cl<strong>in</strong>ical picture<br />

Normal EF/hemos,<br />

no DSA, no rejection<br />

EMBx/echos per<br />

protocol<br />

PRA q 6m<br />

After the dust settles. . .<br />

AMR Ma<strong>in</strong>tenance Protocol<br />

MMF à� PSI<br />

Repeat echo, EMBx,<br />

PRAs 1-2w post rx<br />

Photopheresis<br />

Persistent low EF,<br />

abnormal hemos, or DSA<br />

?<br />

IV Ig, rituximab,<br />

bortezomib

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