Antibody Mediated Rejection in Heart Transplantation
Antibody Mediated Rejection in Heart Transplantation
Antibody Mediated Rejection in Heart Transplantation
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257 samples from<br />
highly sensistized pts<br />
Virtual Xmatch<br />
Prospective vs Virtual Crossmatch<br />
Incompatible<br />
(+)<br />
Compatible<br />
(-)<br />
Prospective Xmatch<br />
Incompatible<br />
(+)<br />
Compatible<br />
(-)<br />
89 23<br />
12 133<br />
89/112<br />
PPV 79%<br />
133/145<br />
NPV 92%<br />
• PPV 79% à� 21% false-<strong>in</strong>compatible rate à� yet donor<br />
pool is still expanded by lack of geographical<br />
constra<strong>in</strong>ts<br />
• NPV 92% à� 8% of patients will have <strong>in</strong>compatible<br />
matches à� use retrospective Xmatch post transplant to<br />
guide therapy<br />
Stehlik et al. J <strong>Heart</strong> and Lung Transplant 2009;28:1129-34.
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