Antibody Mediated Rejection in Heart Transplantation
Antibody Mediated Rejection in Heart Transplantation
Antibody Mediated Rejection in Heart Transplantation
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<strong>Antibody</strong>-<strong>Mediated</strong> <strong>Rejection</strong>:<br />
Summary<br />
• Diagnosis<br />
– Pathological f<strong>in</strong>d<strong>in</strong>gs only<br />
• Prevention<br />
– Assays for specification and quantification of<br />
HLA Ab<br />
– cPRA and virtual crossmatch<br />
– Desensitization target<strong>in</strong>g B cells, plasma cells,<br />
and antibodies<br />
• Treatment<br />
– Subcl<strong>in</strong>ical AMR should be treated<br />
– Long-term therapy: photopheresis vs<br />
densensitization<br />
• Close monitor<strong>in</strong>g for complications
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