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ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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96-well plate<br />

<strong>Tox21</strong> <strong>Screening</strong> g <strong>Throughput</strong> g p<br />

� 8 rows x 12 columns<br />

� 88 test samples<br />

384-well plate<br />

4 x 96-well plates<br />

If @ 100 microtiter plates per day:<br />

samples Time to screen<br />

1 MM samples<br />

§ Plate <strong>for</strong>mat samples /day Time to screen<br />

(wells/day) 1 MM samples<br />

§ Plate <strong>for</strong>mat<br />

/day<br />

(wells/day)<br />

96-well<br />

384-well<br />

1,536-well<br />

8,800 (9,600)<br />

35,200 (38,400)<br />

Office of Research <strong>and</strong> Development<br />

Computational Toxicology Research Program<br />

140,800 (153,600)<br />

4 months<br />

4 weeks<br />

7 days<br />

� 16 rows x 32 columns<br />

� 352 test samples<br />

1536-well plate<br />

16 x 96-well plates<br />

� 32 rows x 48 columns<br />

� 1,408 test samples<br />

§ wells remaining after subtraction of control wells;<br />

NCGC uses left 4 columns of a 1536-well plate <strong>for</strong><br />

control wells<br />

9

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