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ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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Systems Approaches to Modeling Toxicity:<br />

From Pathways to Virtual Tissues<br />

chemicals pathways networks cell states tissue function<br />

Moving beyond<br />

empirical models, to<br />

multi-scale models of<br />

complex biological<br />

systems: vLiver,<br />

vEmbryo…<br />

Office of Research <strong>and</strong> Development<br />

Computational Toxicology Research Program<br />

Identify Key Targets <strong>and</strong> Pathways<br />

For Prioritization<br />

Quantitative<br />

Dose-Response<br />

Models<br />

Next Generation<br />

<strong>Risk</strong> assessments<br />

30<br />

SOT 2010

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