ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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Predictive Signatures from ToxCast for Chronic, Developmental p and Reproductive p Toxicityy • Chronic/Cancer endpoints from rat, mouse and dog • Developmental endpoints from rat and rabbit • Reproductive endpoints from rat Office of Research and Development Computational Toxicology Research Program 23
ToxPi: Prioritizing Chemicals for PPotential t ti l Endocrine E d i Activity A ti it Prioritization Index = ToxPi = f(HTS ( assays y + Chemical properties p p + Pathways) y ) Bisphenol A Tebuthiuron Office of Research and Development Computational Toxicology Research Program Other XME/ADME Other NR LogP_TPSA Predicted CaCO-2 Reif et al, EHP, 2010 TR KEGG pathways ER AR Disease classes Ingenuity pathways
Page 1 and 2: ToxCast and Tox21: High Throughput
Page 3 and 4: Exposure p Grand Challenge for Comp
Page 5 and 6: 4 Robotic Platform Pathway Office o
Page 7 and 8: HTS iin TToxicology i l Test priori
Page 9 and 10: GGoals l of f TToxCast C t and dT T
Page 11 and 12: Comparison p of Volumes for Screeni
Page 13 and 14: ToxCast Phase I ToxCast Phase I and
Page 15 and 16: Assays Chemicals Office of Research
Page 17 and 18: micals Chem Digitizing Legacy in Vi
Page 19 and 20: ToxCast: Multiple Assays and Techno
Page 21 and 22: No Pathology Proliferative Lesions
Page 23: Office of Research and Development
Page 27 and 28: Expanding the ToxPi Approach for Pr
Page 29 and 30: Future ToxPi (Toxicological Priorit
Page 31 and 32: Systems Approaches to Modeling Toxi
Page 33 and 34: Office of Research and Development

ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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