ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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ToxPi Scores for Antimicrobial Pesticide Actives One of the methods be developed to use ToxCast data for classifying and prioritizing antimicrobials and inerts. Office of Research and Development Computational Toxicology Research Program 27
Future ToxPi (Toxicological Prioritization Index) ToxPi = f(Exposure + Chemical properties + In vitro assays + Pathways) Incorporate additional components (slices) ( ) from other domains: - Exposure - Chemical properties - QSAR Office of Research and Development Computational Toxicology Research Program 28
Page 1 and 2: ToxCast and Tox21: High Throughput
Page 3 and 4: Exposure p Grand Challenge for Comp
Page 5 and 6: 4 Robotic Platform Pathway Office o
Page 7 and 8: HTS iin TToxicology i l Test priori
Page 9 and 10: GGoals l of f TToxCast C t and dT T
Page 11 and 12: Comparison p of Volumes for Screeni
Page 13 and 14: ToxCast Phase I ToxCast Phase I and
Page 15 and 16: Assays Chemicals Office of Research
Page 17 and 18: micals Chem Digitizing Legacy in Vi
Page 19 and 20: ToxCast: Multiple Assays and Techno
Page 21 and 22: No Pathology Proliferative Lesions
Page 23 and 24: Office of Research and Development
Page 25 and 26: ToxPi: Prioritizing Chemicals for P
Page 27: Expanding the ToxPi Approach for Pr
Page 31 and 32: Systems Approaches to Modeling Toxi
Page 33 and 34: Office of Research and Development

ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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