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ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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Exposure p<br />

Gr<strong>and</strong> Challenge <strong>for</strong> Computational Toxicology:<br />

PPredicting di ti HHuman TToxicity i it<br />

Tissue<br />

Dose<br />

Office of Research <strong>and</strong> Development<br />

Computational Toxicology Research Program<br />

Complex<br />

Cellular <strong>and</strong><br />

HCS HTS<br />

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Biochemical<br />

HTS<br />

Tissues<br />

Cellular Systems<br />

Molecular<br />

Targets<br />

Cell<br />

Changes<br />

Cellular<br />

Networks<br />

�<br />

Molecular<br />

Pathways<br />

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Cell-Based<br />

HTS<br />

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Model<br />

Organism<br />

MTS<br />

Virtual Tissues<br />

ToxRefDB<br />

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2<br />

Toxicity

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