ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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Biologically Multiplexed Activity Profiling (BioMAP) Multiplex Transcription Reporter Assay Cell-based HTS Assays Cell-free HTS Assays High Content Cell Imaging Assays Office of Research and Development Computational Toxicology Research Program ToxCast: Multiple Targets per Pathway 19
No Pathology Proliferative Lesions Pre-neoplastic Lesions Neoplastic Lesions Office of Research and Development Computational Toxicology Research Program Building Toxicity Signatures for RRat t Li Liver Histopathology Hi t th l from Chronic Bioassays 37 68 21 N = 248 Chemicals in ToxRefDB 20
Page 1 and 2: ToxCast and Tox21: High Throughput
Page 3 and 4: Exposure p Grand Challenge for Comp
Page 5 and 6: 4 Robotic Platform Pathway Office o
Page 7 and 8: HTS iin TToxicology i l Test priori
Page 9 and 10: GGoals l of f TToxCast C t and dT T
Page 11 and 12: Comparison p of Volumes for Screeni
Page 13 and 14: ToxCast Phase I ToxCast Phase I and
Page 15 and 16: Assays Chemicals Office of Research
Page 17 and 18: micals Chem Digitizing Legacy in Vi
Page 19: ToxCast: Multiple Assays and Techno
Page 23 and 24: Office of Research and Development
Page 25 and 26: ToxPi: Prioritizing Chemicals for P
Page 27 and 28: Expanding the ToxPi Approach for Pr
Page 29 and 30: Future ToxPi (Toxicological Priorit
Page 31 and 32: Systems Approaches to Modeling Toxi
Page 33 and 34: Office of Research and Development

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