ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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Exposure HIGH THROUGHPUT SCREENING and CHARACTERIZATION OF HAZARD & RISK Tissue Dose Molecular Targets Molecular Pathways Tissues Cellular Systems Cell Changes Cellular Networks IN VITRO: concentration response Toxicity Human IN SILICO: exposure dose response Animal IN VIVO: exposure dose response Office of Research and Development Computational Toxicology Research Program 31 SOT 2010
Office of Research and Development Computational Toxicology Research Program ToxCast Phase I Publications & Data Release 32 http://epa.gov/ncct/toxcast/ SOT 2010
Page 1 and 2: ToxCast and Tox21: High Throughput
Page 3 and 4: Exposure p Grand Challenge for Comp
Page 5 and 6: 4 Robotic Platform Pathway Office o
Page 7 and 8: HTS iin TToxicology i l Test priori
Page 9 and 10: GGoals l of f TToxCast C t and dT T
Page 11 and 12: Comparison p of Volumes for Screeni
Page 13 and 14: ToxCast Phase I ToxCast Phase I and
Page 15 and 16: Assays Chemicals Office of Research
Page 17 and 18: micals Chem Digitizing Legacy in Vi
Page 19 and 20: ToxCast: Multiple Assays and Techno
Page 21 and 22: No Pathology Proliferative Lesions
Page 23 and 24: Office of Research and Development
Page 25 and 26: ToxPi: Prioritizing Chemicals for P
Page 27 and 28: Expanding the ToxPi Approach for Pr
Page 29 and 30: Future ToxPi (Toxicological Priorit
Page 31: Systems Approaches to Modeling Toxi

ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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