ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...
ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...
ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...
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…<br />
4<br />
Emax<br />
3 2 1 0<br />
Concentration<br />
Office of Research <strong>and</strong> Development<br />
Computational Toxicology Research Program<br />
<strong>ToxCast</strong> Data Analysis<br />
AC50<br />
Chemicalls<br />
Assays<br />
828 Assay-Chemical Pairs<br />
had AC50s of less than 1µM<br />
: Assay-Chemical Hit<br />
500 Assays X 320 Chemicals X {5-18} Concentrations X<br />
{1-3} Replicates X {1-3} Time Points ≈<br />
3.2 Million Data Points<br />
Emax: Maximal efficacy/response/activity<br />
15<br />
AC50: Concentration whereby 50% of maximal response was achieved<br />
Conc (uM): Micromolar concentrations of chemical
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