ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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Office of Research and Development Computational Toxicology Research Program Judson et al, EHP (2010) ToxCast Identied Genes Associated with Progression of Rat Liver Disease Any Lesion Pre-Neoplastic Neoplastic 132 60 21 Liver Disease Progression 21
Office of Research and Development Computational Toxicology Research Program Toxicity Pathways Chemical Receptors p / Enzymes y / etc. Direct Molecular Interaction Pathway Regulation / Genomics Cellular Processes Tissue / Organ / Organism Tox Endpoint 22
Page 1 and 2: ToxCast and Tox21: High Throughput
Page 3 and 4: Exposure p Grand Challenge for Comp
Page 5 and 6: 4 Robotic Platform Pathway Office o
Page 7 and 8: HTS iin TToxicology i l Test priori
Page 9 and 10: GGoals l of f TToxCast C t and dT T
Page 11 and 12: Comparison p of Volumes for Screeni
Page 13 and 14: ToxCast Phase I ToxCast Phase I and
Page 15 and 16: Assays Chemicals Office of Research
Page 17 and 18: micals Chem Digitizing Legacy in Vi
Page 19 and 20: ToxCast: Multiple Assays and Techno
Page 21: No Pathology Proliferative Lesions
Page 25 and 26: ToxPi: Prioritizing Chemicals for P
Page 27 and 28: Expanding the ToxPi Approach for Pr
Page 29 and 30: Future ToxPi (Toxicological Priorit
Page 31 and 32: Systems Approaches to Modeling Toxi
Page 33 and 34: Office of Research and Development

ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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