ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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… 4 Emax 3 2 1 0 Concentration Office of Research and Development Computational Toxicology Research Program ToxCast Data Analysis AC50 Chemicalls Assays 828 Assay-Chemical Pairs had AC50s of less than 1µM : Assay-Chemical Hit 500 Assays X 320 Chemicals X {5-18} Concentrations X {1-3} Replicates X {1-3} Time Points ≈ 3.2 Million Data Points Emax: Maximal efficacy/response/activity 15 AC50: Concentration whereby 50% of maximal response was achieved Conc (uM): Micromolar concentrations of chemical
micals Chem Digitizing Legacy in Vivo Data in ToxRefDB Chronic/Cancer Multigenation Developmental Martin et al 2009a,b Knudsen et al 2009 30 years and more than $2B worth of data 16 Office of Research and Development Computational Toxicology Research Program 16 SOT 2010
Page 1 and 2: ToxCast and Tox21: High Throughput
Page 3 and 4: Exposure p Grand Challenge for Comp
Page 5 and 6: 4 Robotic Platform Pathway Office o
Page 7 and 8: HTS iin TToxicology i l Test priori
Page 9 and 10: GGoals l of f TToxCast C t and dT T
Page 11 and 12: Comparison p of Volumes for Screeni
Page 13 and 14: ToxCast Phase I ToxCast Phase I and
Page 15: Assays Chemicals Office of Research
Page 19 and 20: ToxCast: Multiple Assays and Techno
Page 21 and 22: No Pathology Proliferative Lesions
Page 23 and 24: Office of Research and Development
Page 25 and 26: ToxPi: Prioritizing Chemicals for P
Page 27 and 28: Expanding the ToxPi Approach for Pr
Page 29 and 30: Future ToxPi (Toxicological Priorit
Page 31 and 32: Systems Approaches to Modeling Toxi
Page 33 and 34: Office of Research and Development

ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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