ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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ToxCast and Tox21 High Throughput Screening of Chemical Bioactivity • Addresses chemical screening and prioritization needs for chemicals regulated by EPA • Comprehensive use of HTS technologies to generate biological fingerprints and predictive signatures • Committed to stakeholder involvement and transparency p y • Communities of Practice- Chemical Prioritization; Exposure • Release of all data upon peer review publication Office of Research and Development Computational Toxicology Research Program 7
GGoals l of f TToxCast C t and dT Tox21 21 • Identify y toxicity yppathways y • Obtain HTS assays for pathways • Screen a large chemical library • Initially link HTS results to adverse effects - Toxicity signatures • Ultimately identify points of departure from HTS data - Toxicity pathways Office of Research and Development Computational Toxicology Research Program 8
Page 1 and 2: ToxCast and Tox21: High Throughput
Page 3 and 4: Exposure p Grand Challenge for Comp
Page 5 and 6: 4 Robotic Platform Pathway Office o
Page 7: HTS iin TToxicology i l Test priori
Page 11 and 12: Comparison p of Volumes for Screeni
Page 13 and 14: ToxCast Phase I ToxCast Phase I and
Page 15 and 16: Assays Chemicals Office of Research
Page 17 and 18: micals Chem Digitizing Legacy in Vi
Page 19 and 20: ToxCast: Multiple Assays and Techno
Page 21 and 22: No Pathology Proliferative Lesions
Page 23 and 24: Office of Research and Development
Page 25 and 26: ToxPi: Prioritizing Chemicals for P
Page 27 and 28: Expanding the ToxPi Approach for Pr
Page 29 and 30: Future ToxPi (Toxicological Priorit
Page 31 and 32: Systems Approaches to Modeling Toxi
Page 33 and 34: Office of Research and Development

ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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