ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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• 1536 well HTS • 10,000 chemicals • 25 assays per year Office of Research and Development Computational Toxicology Research Program 11
ToxCast Phase I ToxCast Phase I and II, Tox21 Number of Chemicals ToxCast Phase II Tox21 Actives 272 120 700 Inerts 24 100 1000 Antimicrobials 33 100 500 HPV 35 170 1300 MPV 7 60 1500 Green 4 60 500 PCCL 73 150 500 Pharmaceuticals 0 100 2500 Consumer Products /Food additives 0 0 1500 Total 309 ~700 ~10000 Office of Research and Development Computational Toxicology Research Program 12
Page 1 and 2: ToxCast and Tox21: High Throughput
Page 3 and 4: Exposure p Grand Challenge for Comp
Page 5 and 6: 4 Robotic Platform Pathway Office o
Page 7 and 8: HTS iin TToxicology i l Test priori
Page 9 and 10: GGoals l of f TToxCast C t and dT T
Page 11: Comparison p of Volumes for Screeni
Page 15 and 16: Assays Chemicals Office of Research
Page 17 and 18: micals Chem Digitizing Legacy in Vi
Page 19 and 20: ToxCast: Multiple Assays and Techno
Page 21 and 22: No Pathology Proliferative Lesions
Page 23 and 24: Office of Research and Development
Page 25 and 26: ToxPi: Prioritizing Chemicals for P
Page 27 and 28: Expanding the ToxPi Approach for Pr
Page 29 and 30: Future ToxPi (Toxicological Priorit
Page 31 and 32: Systems Approaches to Modeling Toxi
Page 33 and 34: Office of Research and Development

ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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