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ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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Exp<strong>and</strong>ing the ToxPi Approach <strong>for</strong> Prioritization of Toxicity<br />

Testing Based on <strong>ToxCast</strong> Chemical Profiling<br />

DEVEL<br />

CANCER<br />

PPathways th<br />

associated with<br />

CANCER in vivo<br />

endpoints<br />

In vitro assays<br />

associated with<br />

CANCER in vivo<br />

endpoints<br />

REPRO SYSTEMIC<br />

Office of Research <strong>and</strong> Development<br />

Computational Toxicology Research Program<br />

Identify in vitro assays,<br />

targets, g ,ggenes<br />

<strong>and</strong><br />

pathways associated<br />

with multiple sectors<br />

of in vivo toxicity toxicity.<br />

26

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