Nucleotide Analogs - Jena Bioscience

Recombinant Proteins
210
Interleukin-1β
human, Recombinant, E. coli
Cat. No. Amount Price (€)
PR-401 10 µg 300,--
Supplied in 20 mM Tris-HCl pH 8.0, 5 mM MgCl 2 , 10 %
glycerol, with BSA as a carrier protein.
Interleukins-1 (IL-1) α and β belong to the family of
regulatory and infl ammatory cytokines which play an
important role in the regulation of acute infl ammation.
IL-1β is involved infl ammatory and immune responses
and promotes wound healing.
The closely related proteins IL-1α and IL-1β share
approximately 62% homology in amino acid sequence
but exhibit nearly identical biochemical action.
Purity: ≥ 98% by SDS-PAGE
Store: -80 °C
Selected references:
Bazan et al. (1996) A newly defi ned Interleukin-1. Nature 379:
591.
Arend et al. (1998) Interleukin-1 receptor antgonist - role in
biology. Annu. Rev. Immunol. 16:27.
Dunn (2002) Mechanisms by which cytokines signal the brain.
Neurobiology of the Immune System 52:43.
Interferon γ
(IFNγ)
human, Recombinant, E. coli
Cat. No. Amount Price (€)
PR-420 50 µg 125,--
Supplied in 20 mM Tris-HCl pH 8.0, 5 mM MgCl 2 , 10 %
glycerol, with BSA as a carrier protein.
The cytokine Interferon γ (IFNγ) plays an essential
role in cell mediated immune responses to viral and
mycobacterial infections. IFNγ has no viral speciticity
and inhibits the spread of viruses containing either
RNA or DNA. Upon binding to macrophages IFNγ
enables them to kill intracellular pathogens.
It was also found that IFNγ exhibits antitumor
properties.
Purity: ≥ 98% by SDS-PAGE
Store: -80 °C
Selected references:
Meager et al. (1987) Lymphokines and Interferons, A Practical
Approach., 129.
Roilides et al. (2003) Immunomodulation of invasive fungal
infections. Infectious Disease Clinics of North America 16:193.
Rotondi et al. (2003) Role for interferon-gamma inducible
chemokines in endocrine autoimmunity: An expanding fi eld.
Journal of Endocrinological Investigation 26:177.
Agnello et al. (2003) Cytokines and transcription factors that
regulate T helper cell differentiation: New players and new
insights. Journal of Clinical Immunology 23:147.
Tumor Necrosis Factor α
(TNFα)
human, Recombinant, E. coli
Cat. No. Amount Price (€)
PR-430 50 µg 180,--
Supplied in 20 mM Tris-HCl pH 8.0, 5 mM MgCl 2 , 10 %
glycerol, with BSA as a carrier protein.
Tumor Necrosis Factor α (TNFα), named for its
antitumour properties, is a vital member of the
multifunctional TNF superfamily and has important
roles in immunity and cellular remodelling as well as
infl uencing apoptosis and cell survival. Its central role
in infl ammation has led to the development of TNFα
antagonists as effective therapies for rheumatoid
arthritis and infl ammatory bowel disease.
It is known that TNFα is a crucial cytokine in the
establishment an maintenance of infl ammation in
multiple autoimmune diseases.
In addition to its established role in the immune
system, TNFα exerts complex regulatory actions
on adipose tissue. TNFα affects many aspects of
adipocyte function, from adipocyte development to
lipid metabolism.
Purity: ≥ 98% by SDS-PAGE
Store: -80 °C
Selected references:
Meager et al. (1987) Lymphokines and Interferons, A Practical
Approach., 129.
Roilides et al. (2003) Immunomodulation of invasive fungal
infections. Infectious Disease Clinics of North America 16:193.
Reimold A.M. (2002) TNFalpha as therapeutic target: new
drugs, more applications. Curr. Drug Targets Infl amm. Allergy
1:377.
Szlosarek P.W. and Balkwill F.R. (2003) Tumor necrosis factor
alpha: a potential target for the therapy of solid tumours. Lancet
Oncol. 4:565.
Warne J.P. (2003) Tumor necrosis factor alpha: a key regulator
of adipose tissue mass. J. Endocrinol. 177:351.
Agnello et al. (2003) Cytokines and transcription factors that
regulate T helper cell differentiation: New players and new
insights. Journal of Clinical Immunology 23:147.
Tumor Necrosis Factor α
(TNFα)
mouse, Recombinant, S. lividans
Cat. No. Amount Price (€)
PR-431 50 µg 180,--
Supplied in 20 mM Tris-HCl pH 8.0, 5 mM MgCl 2,
10 % glycerol.
Tumor Necrosis Factor α (TNFα), named for its
antitumour properties, is a vital member of the
multifunctional TNF superfamily and has important
roles in immunity and cellular remodelling as well as
infl uencing apoptosis and cell survival. Its central role
in infl ammation has led to the development of TNFα
antagonists as effective therapies for rheumatoid
arthritis and infl ammatory bowel disease.
It is known that TNFα is a crucial cytokine in the
establishment an maintenance of infl ammation in
multiple autoimmune diseases.
In addition to its established role in the immune
system, TNFα exerts complex regulatory actions
on adipose tissue. TNFα affects many aspects of
adipocyte function, from adipocyte development to
lipid metabolism.
Purity: ≥ 98% by SDS-PAGE
Store: -80 °C
Selected references:
Meager et al. (1987) Lymphokines and Interferons, A Practical
Approach., 129.
Mueller et al. (1999) Noncleavable Transmembrane Mouse
Tumor Necrosis Factor-α (TNFα) Mediates Effects Distinct
from Those of Wild-type TNFα in Vitro and in Vivo. J. Biol.
Chem..274:38112.
Reimold A.M. (2002) TNFalpha as therapeutic target: new
drugs, more applications. Curr. Drug Targets Infl amm. Allergy
1:377.
Szlosarek P.W. and Balkwill F.R. (2003) Tumor necrosis factor
alpha: a potential target for the therapy of solid tumours. Lancet
Oncol. 4:565.
Warne J.P. (2003) Tumor necrosis factor alpha: a key regulator
of adipose tissue mass. J. Endocrinol. 177:351.
Agnello et al. (2003) Cytokines and transcription factors that
regulate T helper cell differentiation: New players and new
insights. J. Clin. Immunol. 23:147.
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