Nucleotide Analogs - Jena Bioscience

2’I-ATP
2’-Iodo-adenosine-5’-triphosphate, Sodium salt
Cat. No. Amount (Units) Price (€)
NU-101S 30 75,--
NU-101L 150 300,--
Molecular Formula: C 10 H 12 N 5 O 12 P 3 I (Anion)
Molecular Weight: 614.05 (Anion)
O
O O
P P P
HO O O O
O O O
3 Na
O
OH I
N
N
NH 2
Selected references:
Naber et al. (1995) A novel adenosine-triphosphate analog with
a heavy-atom to target the nucleotide-binding site of proteins.
Protein Sci. 4:1824.
8I-ATP
8-Iodo-adenosine-5’-triphosphate, Sodium salt
Cat. No. Amount (Units) Price (€)
NU-113S 50 75,--
NU-113L 250 300,--
Molecular Formula: C 10 H 12 N 5 O 13 P 3 I (Anion)
Molecular Weight: 630.05 (Anion)
O
3 Na
O O
P P P
HO O O O
O O O
8Br-ATP
I
O
OH OH
8-Bromo-adenosine-5’-triphosphate, Sodium salt
N
N
N
N
N
NH2
Cat. No. Amount (Units) Price (€)
NU-114S 100 75,--
NU-114L 500 300,--
Molecular Formula: C 10 H 12 N 5 O 13 P 3 Br (Anion)
Molecular Weight: 583.05 (Anion)
O
3 Na
O O
P P P
HO O O O
O O O
Br
O
OH OH
N
N
N
N
NH2
Selected references:
Carrasco et al. (1998) Interaction of adenosine nucleotide
analogs with Saccharomyces cerevisiae phosphoenolpyruvate
carboxykinase. BBA-Protein Struct. M. 1429 (1):93.
Maruta et al. (1998) Characterization of the interaction of
myosin with ATP analogues having the syn conformation with
respect to the adenine-ribose bond. Eur. J. Biochem. 256 (1):
229.
Juodka et al. (1993) Substrate-specifi city of T4 RNA-ligase –
role of the purine base of the nucleotide in formation of the
covalent AMP-RNA-ligase complex. Biochemistry-Moscow
58 (6):576.
N
Beukers et al. (1993) Characterization of ecto-ATPase on
human blood-cells - a physiological-role in platelet-aggregation.
Biochem. Pharmacol. 46 (11):1959.
Homas et al. (1991) A receptor that is highly specifi c for
extracellular ATP in developing chick skeletal-muscle invitro.
Brit. J. Pharmacol. 103 (4):1963.
Champeil et al. (1988) ATP regulation of sarcoplasmic-reticulum
Ca-2+-ATPase – metal-free ATP and 8-bromo-ATP bind with
high-affi nity to the catalytic site of phosphorylated ATPase and
accelerate dephosphorylation. J. Biol. Chem. 263 (25):12288.
Szilagyi et al. (1988) Effect of 8-Br-ATP as a bound nucleotide
on the molecular-dynamics of actin. J. Muscle Res. Cell M. 9
(1):93.
Kuryavyi et al. (1987) Infl uence of 8-Br-ATP and 8-Oxy-
ATP on rna-synthesis by escherichia-coli rna-polymerase.
Biochemistry-Moscow 52 (1):127.
Kuryavy et al. (1984) Effect of 8-Bromo-ATP on RNA-synthesis
by Escherichia-coli RNA-polymerase invitro. Stud. Biophys.
101:165.
Bruskov et al. (1982) Recognition of 8-Bromo-ATP in the RNApolymerase
reaction. Stud. Biophys. 87 (2-3):173.
Nagel et al. (1976) Chromatographic investigation of substrate
properties of 8-Bromo-ATP in nucleoside diphosphate kinase
reaction. J. Clin. Chem. Clin. Bio. 14 (9):429.
2’I-AppNHp (2’I-AMPPNP)
2’-Iodo-adenosine-5’-[(β,γ)-imido]triphosphate,
Sodium salt
Cat. No. Amount (Units) Price (€)
NU-103S 20 75,--
NU-103L 100 300,--
Molecular Formula: C 10 H 13 N 6 O 11 P 3 I (Anion)
Molecular Weight: 613.07 (Anion)
O
O O
P P P
HO NH O
O O O
3 Na
O
O
OH I
N
N
NH 2
Selected references:
Gruen et al. (1999) 2’-Halo-ATP and -GTP analogues: Rational
phasing tools for protein crystallography. Protein Sci. 8:2524.
Gruen et al. (1999) Synthesis of 2’-iodo- and 2’-bromo-ATP
and GTP analogues as potential phasing tools for X-ray
crystallography. Nucleos. Nucleot. 18 (1):137.
2’Br-AppNHp (2’Br-AMPPNP)
2’-Bromo-adenosine-5’-[(β,γ)-imido]triphosphate,
Sodium salt
Cat. No. Amount (Units) Price (€)
NU-104S 20 75,--
NU-104L 100 300,--
Molecular Formula: C 10 H 13 N 6 O 11 P 3 Br (Anion)
Molecular Weight: 566.07 (Anion)
O
O O
P P P
HO NH O
O O O
3 Na
O
O
OH Br
N
N
N
N
N
NH 2
Selected references:
Gruen et al. (1999) 2’-Halo-ATP and -GTP analogues: Rational
phasing tools for protein crystallography. Protein Sci. 8:2524.
Gruen et al. (1999) Synthesis of 2’-iodo- and 2’-bromo-ATP
and GTP analogues as potential phasing tools for X-ray
crystallography. Nucleos. Nucleot. 18 (1):137.
N
8I-AppNHp (8I-AMPPNP)
8-Iodo-adenosine-5’-[(β,γ)-imido]triphosphate,
Sodium salt
Cat. No. Amount (Units) Price (€)
NU-115S 20 75,--
NU-115L 100 300,--
Molecular Formula: C 10 H 13 N 6 O 12 P 3 I (Anion)
Molecular Weight: 629.07 (Anion)
O
O O
P P P
HO NH O
O O O
3 Na
O
I
O
OH OH
8Br-AppNHp (8Br-AMPPNP)
8-Bromo-adenosine-5’-[(β,γ)-imido]triphosphate,
Sodium salt
N
N
NH 2
Cat. No. Amount (Units) Price (€)
NU-116S 20 75,--
NU-116L 100 300,--
Molecular Formula: C 10 H 13 N 6 O 12 P 3 Br (Anion)
Molecular Weight: 582.07 (Anion)
O
O O
P P P
HO NH O
O O O
3 Na
8Br-cAMP
O
Br
O
OH OH
N
N
N
N
NH 2
8-Bromo-Adenosine-3’,5’-cyclic monophosphate,
Sodium salt
Cat. No. Amount Price (€)
NU-1502S 10 mg 75,--
NU-1502L 50 mg 300,--
Molecular Formula: C 10 H 10 N 5 O 6 PBr (Anion)
Molecular Weight: 407.09 (Anion)
O
Halogen containing Nucleotides
O
P
O
O
Na
Br
O
OH
N
N
NH2
Selected references:
Paz et al. (1999) Corticotropin increases protein tyrosine
phosphatase activity by a cAMP-dependent mechanism in rat
adrenal gland. Eur. J. Biochem. 265:911.
Martin et al. (1999) Comparison of expression and regulation of
the high-density lipoprotein receptor SR-BI and the low-density
lipoprotein receptor in human adrenocortical carcinoma NCI-
H295 cells. Eur. J. Biochem. 261:481.
Chen et al. (1998) Up-regulation of the cAMP/PKA pathway
inhibits proliferation, induces differentiation, and leads to
apoptosis in malignant gliomas. Lab. Invest. 78:165.
N
N
N
N
49
Nucleotide Analogs