Nucleotide Analogs - Jena Bioscience

More documents

Recommendations

Info

anti-p53 rabbit polyclonal antibody Cat. No. Amount Price (€) ABD-015 50 µg 400,-- Liquid. Supplied in PBS. p53 was identifi ed as a tumor suppressor by showing to block the transformation and to inhibit tumor cell growth. In addition, this protein is a transcription factor capable of regulating the expression of a subset of downstream genes. Different mutations in p53 gene have been characterized in a variety of human cancers. Loss or mutation of p53 function is highly correlated with tumorigenesis. α-p53 is an affi nity-purifi ed rabbit polyclonal antibody raised against the recombinant p53 protein. Specifi city α-p53 reacts with the p53 protein in HeLa nuclear extract (cat.# PR-777) by Western blotting. Recommended dilution range for Western blot analysis: 1:200 - 1:1000. Store: -20 °C Selected references: Finlay et al. (1989) The p53 proto-oncogene can act as a suppressor of transformation. Cell 57:1083. Michalovitz et al. (1990) Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell 62:671. Baker et al. (1990) Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249:912. Fields et.al. (1990) Presence of a potent transcription activating sequence in the p53 protein. Science 249:1046. Raycroft et al. (1990) Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science 249:1049. Hollstein et al. (1991) p53 mutations in human cancers. Science 253:49. Bennett et al. (1992) Mutational spectra and immunohistochemical analyses of p53 in human cancers. Chest 101:19S. anti-VHL rabbit polyclonal antibody Cat. No. Amount Price (€) ABD-016 50 µg 400,-- Liquid. Supplied in PBS. Von Hippel-Lindau (VHL) disease is a hereditary cancer with a predilection for the central nervous system and retina. The von Hippel-Lindau tumor suppressor gene is mutated in families with von Hippel-Lindau disease and encodes a protein (VHL) of 213 amino acids with an acidic pentapeptide motif in the N-terminus. Mutations in the VHL gene result in constitutive expression of many hypoxi-induced genes, at least in part because of increases in the cellular level of hypoxia-inducible transcription factor HIF-1α. VHL protein binds to elongin B, elongin C, and Cul2 to form a stable complex that targets hypoxia inducibal factors (HIFs) for degradation and transcriptional regulation. In addition, VHL protein has also been shown to interact with specifi c protein kinase C isoforms, histone deacetylases and HIF-1 inhibitor (FIH-1). α-VHL is an affi nity-purifi ed rabbit polyclonal antibody raised against the recombinant VHL protein. Specifi city α-VHL reacts with the VHL protein in HeLa nuclear extract (cat.# PR-777) by Western blotting. Recommended dilution range for Western blot analysis: 1:200 - 1:1000. Store: -20 °C Selected references: Singh et al. (2001) von Hippel-Lindau disease. Survey of Ophthalmology 46:117. Latif et al. (1993) Identifi cation of the von Hippel-Lindau disease tumor suppressor gene. Science 260:1317. Linehan et al. (1995) Identifi cation of the von Hippel-Lindau (VHL) gene. Its role in renal cancer. J. Am. Med. Assoc. 273: 564. Duan et al. (1995) Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations. Proc. Natl. Acad. Sci. USA 92:6459. Kamura et al. (2000) Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc. Natl. Acad. Sci. USA 97:10430. Duan et al. (1995) Inhibition of transcription elongation by the VHL tumor suppressor protein. Science 269:1402. Iwai et al. (1999) Identifi cation of the von Hippel-lindau tumorsuppressor protein as part of an active E3 ubiquitin ligase complex. Proc. Natl. Acad. Sci. USA 96:12436. Pal et al. (1997) The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways. J Biol. Chem. 272:27509. Mahon et al. (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes & Dev. 15:2675. anti-PC4 rabbit polyclonal antibody, serum Cat. No. Amount Price (€) ABD-017 100 µl 400,-- Liquid. Supplied as serum. The human PC4 (also called p15) is a non-TAF transcription coactivator that mediates activatordependent transcription by RNA Polymerase II in vitro through most tested activators. The function of PC4 is apparently through interactions with transcriptional activators and the basal transcription machinery. It is negatively regulated by casein kinase II phosphorylation both in vivo and in vitro. PC4 strongly binds single stranded DNA and regulates HSSB (RPA)-dependent SV40 DNA replication. Recent studies indicated that PC4 can be acetylated by several histone acetyltransferase. α-PC4 is rabbit polyclonal seum raised against the recombinant full-length PC4 protein. Specifi city α-PC4 reacts with the PC4 protein in HeLa nuclear extract (cat.# PR-777) by Western blotting. Recommended dilution range for Western blot analysis: 1:2000 - 1:5000. Store: -20 °C Selected references: Ge H. and Roeder R.G. (1994) Purifi cation, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell 78:513. Ge et al. (1994) Phosphorylation negatively regulates the function of coactivator PC4. Proc. Natl. Acad. Sci. USA 91: 12691. Kretzschmar et al. (1994) A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators. Cell 78:525. Wu S.Y. and Chiang C.M. (1998) Properties of PC4 and an RNA polymerase II complex in directing activated and basal transcription in vitro. J. Biol. Chem. 273:12492. Brandsen et al. (1997) C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site. Nat. Struct. Biol. 4:900. Werten et al. (1998) Interaction of PC4 with melted DNA inhibits transcription. EMBO J. 17:5103. anti-SC35 rabbit polyclonal antibody Antibodies Cat. No. Amount Price (€) ABD-018 50 µg 400,-- Liquid. Supplied in PBS. SC35, a member of SR protein family, is an essential pre-mRNA splicing factor and can function as an essential splicing factor as well as an alternative splicing factor. Phosphorylation on serine residues located within the SR domain directly regulates SC35 activity and compartmentalization of other SR splicing factors. In addition to interacting with RNA and other splicing factors, SC35 has been shown to interact either directly or indirectly interacts with the C-terminal domain (CTD) of the largest subunit of RNA Polymerase II, thereby suggesting a potential role of SC35 in coordinating of transcription and pre-mRNA splicing. α-SC35 is an affi nity-purifi ed rabbit polyclonal antibody raised against the recombinant SC35 protein. Specifi city α-SC35 reacts with the SC35 protein in HeLa nuclear extract (cat.# PR-777) by Western blotting. Recommended dilution range for Western blot analysis: 1:200 - 1:1000. Store: -20 °C Selected references: Fu et al. (1992) Isolation of a complementary DNA that encodes the mammalian splicing factor SC35. Science 256:535. Zahler et al. (1992) SR proteins: a conserved family of premRNA splicing factors. Genes & Dev. 6:837. Gui et al. (1994) Purifi cation and characterization of a kinase specifi c for the serine- and arginine-rich pre-mRNA splicing factors. Proc. Natl. Acad. Sci. USA 91:10824. Colwill et al. (1996) The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J. 15:265. Misteli et al. (1997) The dynamics of a pre-mRNA splicing factor in living cells. Nature 387:523. Antibodies 239
Antibodies 240 PI3 Kinase Antibodies anti-hPI(3)Kγ (mAb p110γ) (anti-human Phosphoinositide 3-kinase gamma) mouse monoclonal antibody, IgG2a, clone H1 Cat. No. Amount Price (€) ABD-026S 200 µl 70,-- ABD-026L 1 ml 280,-- Liquid. Supplied as cell culture supernatant in Dulbecco’s modifi ed Eagles medium, 10% FCS, 0.03% sodium azide. Monoclonal Antibody (mAb) p110γ is a mouse IgG2a subtype antibody. Immunogen: Synthetic peptide corresponding to a part of human PI(3)Kγ (p110γ). Specifi city: mAb p110γ recognizes the sequence aa 97-335 of the human and mouse PI(3)Kγ (p110γ). The antibody does not cross-react with p110α, p110β and p110δ. Purity: 5% IgG as determined by SDS-gel electrophoresis. Storage: For long term storage, the antibody should be kept at 4°C. Application: mAb p110γ can be used for Western blotting at a dilution of 1: 500. Selected reference: Leopoldt D. et al. (1998) G βγ stimulates phosphoinositide 3kinase-gamma by direct interaction with two domains of the catalytic p110 subunit. J. Biol. Chem. 273:7024. Protein Kinase Antibodies anti-human protein kinase CK2α-subunit mouse monoclonal antibody Cat. No. Amount Price (€) ABD-019 50 µg 160,-- Supplied lyophilized from PBS. anti-CK2α is a murine monoclonal antibody (MAb) that was produced against the recombinant human α-subunit of protein kinase CK2 (casein kinase), a pleiotropic and constitutively active serine/threonine protein kinase. The antibody is an affi nity-purifi ed IgG (by protein A agarose), the epitope was mapped to (319)MEHPYF(324). Immunogen: SDS-denatured, purifi ed recombinant human CK2α-subunit. Cross-reactivity: Bovine, mouse, rat, hamster (so far tested). Handling and use: Reconstitute in ddH 2 O Western Blot: 0.2 µg/ml Immunocytochemistry: 12 µg/ml Store: -20 °C Selected references: Schmidt-Spaniol et al. (1992) Isolation and characterization of a monoclonal anti CK-2 alpha subunit antibody of the IgG1 subclass. Hybridoma. 11:53. Nastainczyk et al. (2002) Epitope analysis of the MAb 1AD9 antibody detection site in human protein kinase CK2alphasubunit. Hybrid. Hybridomics. 22:87. anti-human protein kinase CK2β-subunit mouse monoclonal antibody Cat. No. Amount Price (€) ABD-020 50 µg 160,-- Supplied lyophilized from PBS. anti-CK2β is a murine monoclonal antibody (MAb) that was produced against the recombinant human β-subunit of protein kinase CK2 (casein kinase), a pleiotropic and constitutively active serine/threonine protein kinase. The antibody is an affi nity-purifi ed IgG (by protein A agarose), the epitope was mapped to (123)GLSDI(127). Immunogen: Purifi ed recombinant human CK2β-subunit. Cross-reactivity: Bovine, mouse, rat, hamster (so far tested). Handling and use: Reconstitute in ddH 2 O Western Blot: 0.2 µg/ml Immunocytochemistry: 12 µg/ml Store: -20 °C Selected reference: Nastainczyk et al. (1995) Isolation and characterization of a monoclonal anti-protein kinase CK2 beta-subunit antibody of the IgG class for the direct detection of CK2 beta-subunit in tissue cultures of various mammalian species and human tumors. Hybridoma. 14:335. http://www.jenabioscience.com Cytokine Antibodies anti-human Interleukin-1β (anti-hIL-1β) rabbit polyclonal antibody Cat. No. Amount Price (€) ABD-023 50 µl 160,-- Liquid. Supplied in Serum Polyclonal antibody anti-hIL-1β is a human Interleukin-1β specifi c rabbit IgG antibody. Antigen: E. coli expressed human Interleukin-1β Applications: anti-hIL-1β may be used for Western blotting and ELISA at a dilution of 1:10000-1:50000 Storage: For long term storage, the antibody should be kept at 4 °C or 20 °C Selected reference: Wu P et al. (2004) Toward immobilized antibody microarray optimization: print buffer and storage condition comparisons on performance. Biomed. Sci. Instrum. 40:243. anti-hTNFα (anti-human Tumor Necrosis Factor-α) rabbit polyclonal antibody Cat. No. Amount Price (€) ABD-024 50 µl 160,-- Liquid. Supplied in Serum Polyclonal antibody anti-hTNFα is a human TNFα specifi c rabbit IgG antibody. Antigen: E. coli expressed human TNFα Applications: anti-hTNFα may be used for Western blotting and ELISA at a dilution of 1:10000 - 1:30000 Storage: For long term storage, the antibody should be kept at 4°C or 20°C. Selected reference: Wu P et al. (2004) Toward immobilized antibody microarray optimization: print buffer and storage condition comparisons on performance. Biomed. Sci. Instrum. 40:243. anti-TNFα α-Tumor Necrosis Factor α (anti-mouseTumor Necrosis Factor α) rabbit polyclonal antibody Cat. No. Amount Price (€) ABD-025 50 µl 160,-- Liquid. Supplied in Serum Polyclonal antibody anti-mTNF-α is a mouse TNF-α specifi c rabbit IgG antibody. Antigen: E. coli expressed mouse TNF-α Applications: anti-mTNF-α may be used for Western blotting and ELISA at a dilution of 1:10000-1:50000 Storage: For long term storage, the antibody should be kept at 4°C or 20°C. Selected reference: Hassoun E et al. (2000) Ricin-induced toxicity in the macrophage J744A.1 cells: the role of TNF-alpha and the modulation effects of TNF-alpha polyclonal antibody. J. Biochem. Mol. Toxicol. 14:95.
Page 1 and 2:
JENA BIOSCIENCE Nucleotides and the
Page 3 and 4:
2 Imprint: Design and Layout by: Gr
Page 5 and 6:
Fax Order Form 4 Jena Bioscience Fa
Page 7 and 8:
Terms/Conditions 6 General Business
Page 9 and 10:
8 http://www.jenabioscience.com
Page 11 and 12:
Nucleotide Analogs 10 General Infor
Page 13 and 14:
Nucleotide Analogs 12 Fluorescent C
Page 15 and 16:
Nucleotide Analogs 14 Labeled Amino
Page 17 and 18:
Nucleotide Analogs 16 Labeled Cytid
Page 19 and 20:
Nucleotide Analogs 18 Labeled γ-Am
Page 21 and 22:
Nucleotide Analogs 20 Labeled with
Page 23 and 24:
Page 25 and 26:
Page 27 and 28:
Nucleotide Analogs 26 Intrinsically
Page 29 and 30:
Nucleotide Analogs 28 Selected refe
Page 31 and 32:
Nucleotide Analogs 30 mant-GTPγS 2
Page 33 and 34:
Nucleotide Analogs 32 http://www.je
Page 35 and 36:
Nucleotide Analogs 34 Labeled Cytid
Page 37 and 38:
Nucleotide Analogs 36 Labeled 8-[(4
Page 39 and 40:
Nucleotide Analogs 38 Non-hydrolyza
Page 41 and 42:
Nucleotide Analogs 40 dATPαS 2‘-
Page 43 and 44:
Nucleotide Analogs 42 Selected refe
Page 45 and 46:
Nucleotide Analogs 44 XTPγS Xantho
Page 47 and 48:
Nucleotide Analogs 46 Bisubstrate I
Page 49 and 50:
Nucleotide Analogs 48 Halogen conta
Page 51 and 52:
Nucleotide Analogs 50 Hei et al. (1
Page 53 and 54:
Nucleotide Analogs 52 Amine-labeled
Page 55 and 56:
Nucleotide Analogs 54 Other Bases
Page 57 and 58:
Nucleotide Analogs 56 dATPαS 2‘-
Page 59 and 60:
Nucleotide Analogs 58 γ-Aminohexyl
Page 61 and 62:
Nucleotide Analogs 60 Adenosine Nuc
Page 63 and 64:
Nucleotide Analogs 62 d4TTP 2’,3
Page 65 and 66:
Nucleotide Analogs 64 6-Thio-GTP 6-
Page 67 and 68:
Nucleotide Analogs 66 Cyclic Nucleo
Page 69 and 70:
Nucleotide Analogs 68 m 7 GTP 7-Met
Page 71 and 72:
Nucleotide Analogs 70 XTP Xanthosin
Page 73 and 74:
Nucleotide Analogs 72 Vial et al. (
Page 75 and 76:
Nucleotide Analogs 74 Non-modifi ed
Page 77 and 78:
Page 79 and 80:
Macromolecular Crystallography 78 C
Page 81 and 82:
Macromolecular Crystallography 80 J
Page 83 and 84:
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
Page 93 and 94:
Page 95 and 96:
Macromolecular Crystallography 94 W
Page 97 and 98:
Macromolecular Crystallography 96 O
Page 99 and 100:
Page 101 and 102:
Macromolecular Crystallography 100
Page 103 and 104:
Page 105 and 106:
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
LEXSY 116 http://www.jenabioscience
Page 119 and 120:
LEXSY 118 http://www.jenabioscience
Page 121 and 122:
LEXSY 120 Secretory expression of t
Page 123 and 124:
LEXSY 122 Synthetic serum- and prot
Page 125 and 126:
LEXSY 124 Important licensing infor
Page 127 and 128:
Recombinant Proteins 126 GTP Signal
Page 129 and 130:
Recombinant Proteins 128 K-Ras 4B h
Page 131 and 132:
Recombinant Proteins 130 Rab17 mous
Page 133 and 134:
Recombinant Proteins 132 Selected r
Page 135 and 136:
Recombinant Proteins 134 WASP-121 G
Page 137 and 138:
Recombinant Proteins 136 G sαS -Le
Page 139 and 140:
Recombinant Proteins 138 Store: -80
Page 141 and 142:
Recombinant Proteins 140 Wenzel-Sei
Page 143 and 144:
Recombinant Proteins 142 Mutation o
Page 145 and 146:
Recombinant Proteins 144 Naunyn- Sc
Page 147 and 148:
Recombinant Proteins 146 Protein co
Page 149 and 150:
Recombinant Proteins 148 Membrane P
Page 151 and 152:
Recombinant Proteins 150 TBP (TATA
Page 153 and 154:
Recombinant Proteins 152 Store: -80
Page 155 and 156:
Recombinant Proteins 154 RAP30 can
Page 157 and 158:
Recombinant Proteins 156 and contai
Page 159 and 160:
Recombinant Proteins 158 BRCA1 (Tum
Page 161 and 162:
Recombinant Proteins 160 Unit defi
Page 163 and 164:
Recombinant Proteins 162 p53, wild
Page 165 and 166:
Recombinant Proteins 164 Sp1 (GC-bo
Page 167 and 168:
Recombinant Proteins 166 p52 (Trans
Page 169 and 170:
Recombinant Proteins 168 Topo I (Hu
Page 171 and 172:
Recombinant Proteins 170 HMG1 (High
Page 173 and 174:
Recombinant Proteins 172 Splicing F
Page 175 and 176:
Recombinant Proteins 174 Lim-Tio et
Page 177 and 178:
Recombinant Proteins 176 GST-LXRα-
Page 179 and 180:
Recombinant Proteins 178 Unit defi
Page 181 and 182:
Recombinant Proteins 180 Purity: >
Page 183 and 184:
Recombinant Proteins 182 PI3 Kinase
Page 185 and 186:
Recombinant Proteins 184 Selected r
Page 187 and 188:
Recombinant Proteins 186 L-α-Phosp
Page 189 and 190: Recombinant Proteins 188 , Tyrosine
Page 191 and 192: Recombinant Proteins 190 Purity: >
Page 193 and 194: Recombinant Proteins 192 p42/ERK2/M
Page 195 and 196: Recombinant Proteins 194 Akt3/PKBγ
Page 197 and 198: Recombinant Proteins 196 CK2 substr
Page 199 and 200: Recombinant Proteins 198 PTP 1B is
Page 201 and 202: Recombinant Proteins 200 Prion Prot
Page 203 and 204: Recombinant Proteins 202 Ovine (She
Page 205 and 206: Recombinant Proteins 204 bovPrPc cD
Page 207 and 208: Recombinant Proteins 206 HIV-1 Nef
Page 209 and 210: Recombinant Proteins 208 Antioxidan
Page 211 and 212: Recombinant Proteins 210 Interleuki
Page 213 and 214: Enzymes 212 Restriction Enzymes Res
Page 215 and 216: Enzymes 214 http://www.jenabioscien
Page 217 and 218: Enzymes 216 Restriction Enzymes Buf
Page 219 and 220: Enzymes 218 Relative Activity of Re
Page 221 and 222: Enzymes 220 Acc I 5’...GTMKAC...3
Page 223 and 224: Enzymes 222 EcoR V 5’...GATATC...
Page 225 and 226: Enzymes 224 Sca I 5’...AGTACT...3
Page 227 and 228: Enzymes 226 Selected references: Br
Page 229 and 230: Enzymes 228 GST-RPB9 (RNA Polymeras
Page 231 and 232: Enzymes 230 T4 dNMP kinase Bacterio
Page 233 and 234: Enzymes 232 Topo I Core (Human DNA
Page 235 and 236: 234 http://www.jenabioscience.com
Page 237 and 238: Antibodies 236 Transcription Factor
Page 239: Antibodies 238 anti-Dr1 rabbit poly
Page 243 and 244: 242 http://www.jenabioscience.com
Page 245 and 246: PCR related Products 244 Standard P
Page 247 and 248: PCR related Products 246 DNA Mutage
Page 249 and 250: PCR related Products 248 Polymerase
Page 251 and 252: PCR related Products 250 Primers an
Page 253 and 254: PCR related Products 252 DNA Sequen
Page 255 and 256: PCR related Products 254 50 bp DNA
Page 257 and 258: Affi nity Chromatography 256 Immobi
Page 261 and 262: Affi nity Chromatography 260 γ-Ami
Page 265 and 266: Affi nity Chromatography 264 γ-Ami
Page 269 and 270: Affi nity Chromatography 268 2’/3
Page 271 and 272: Index 270 Product Catalog number Pa
Page 273 and 274: Index 272 Labeled 5-Propargylamino-
Page 275 and 276: Index 274 Labeled EDA-ATP + 5-FAM..
Page 277 and 278: Index 276 Labeled γ-Aminooctyl-dUT
Page 279 and 280: Index 278 Constitutive LEXSY Starte
Page 281 and 282: Index 280 PrPc (full length, residu
Page 283 and 284: Index 282 dPTP, L pack ............
Page 285 and 286: Index 284 Catalog number Product Pa
Page 287 and 288: Index 286 CC-105 JBScreen Cryo 3 ..
Page 289 and 290: Index 288 NU-1014L NTP bundle (larg
Page 291 and 292:
Index 290 NU-407S AppNHp (AMPPNP) .
Page 293 and 294:
Index 292 NU-810-540Q Labeled EDA-A
Page 295 and 296:
Index 294 NU-819L γ-Aminoethyl-App
Page 297 and 298:
Index 296 PR-306 RCC1 (RanGEF) ....
show all

Nucleotide Analogs - Jena Bioscience

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?