Electronic Posters: Neuroimaging - ismrm

15:00 4269. Decreased Brain Glx Levels in HIV Dementia: A 3 Tesla MR Spectroscopy Study
Mona Adel Mohamed 1,2 , Peter B. Barker 1,2 , Richard L. Skolasky 3 , Richard T. Moxley 3 ,
Martin G. Pomper 1 , Ned C. Sacktor 3
1 Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2 Kennedy Krieger
Institute, FM Kirby Center for Functional Brain Imaging, Baltimore, MD, United States; 3 Neurology, Johns
Hopkins University School of Medicine, Baltimore, MD, United States
The major finding of the current study is that brain MRS performed at 3T reveals decreased levels of Glx in the frontal white matter
(FWM) of patients with HIV-associated dementia (HAD) compared to those without dementia. FWM Glx decreases were also
associated with poorer cognitive function, specifically impaired executive and fine motor functioning in HAD. 3T MRS measurements
of Glx may be a useful indicator of neuronal loss or dysfunction in patients with HIV infection.
Thursday 13:30-15:30 Computer 73
13:30 4270. Widespread and Different Distribution of Extrafocal NAA/(Cr+Cho) Reductions in
Mesial Temporal Lobe Epilepsy (TLE) with and Without Mesial Temporal Sclerosis
Susanne G. Mueller 1 , Andreas Ebel 1 , Jerome Barakos 2 , Cathy Scanlon 1 , Ian Cheong 1 ,
Daniel Finaly 1 , Paul Garcia 3 , Michael W. Weiner 1 , Kenneth D. Laxer 2
1 Dept. of Radiology and Biomedical Imaging, UCSF, Center for Imaging of Neurodegenerative Diseases, San
Francisco, CA, United States; 2 Pacific Epilepsy Program, Califronia Pacific Medical Center; 3 Department of
Neurology, UCSF
14 TLE with mesial temporal lobe sclerosis (TLE-MTS)and 14 TLE with normal appearing hippocampi (TLE-no) and 18 healthy
volunteers were studied with a whole brain 3D EPSI at 4T. Widespread NAA/(Cr+Cho) reductions showing a considerable
intersubject variability were found in both groups. The distribution of these abnormalities was different in the two TLE groups. These
findings indicate that TLE-MTS and TLE-no are metabolically heterogeneous and might even represent different TLE entities.
14:00 4271. Voxel-Based Analysis of Magnetisation Transfer Ratio as a Potential Biomarker in
Prion Diseases.
Harpreet Hyare 1 , Enrico De Vita 2 , Gerard Ridgway 3 , Rachael Scahill 4 , Durrenajaf
Siddique 1 , Simon Mead 1 , Peter Rudge 1 , Tarek Yousry 2 , John Collinge 1 , John Thornton 5
1 MRC Prion Unit, UCL Institute of Neurology, London, United Kingdom; 2 National Hospital for Neurology
and Neurosurgery; 3 Dementia Research Centre, UCL Institute of Neurology; 4 Department of Neurodegenerative
Diseases, UCL Institute of Neurology; 5 National Hospital for Neurology and Neurosurgery, London, United
Kingdom
Voxel based morphometry in inherited prion diseases demonstrates regionally specific atrophy in the basal ganglia, cerebellum and
posterior cortical areas but no significant differences in the white matter compared to controls. Voxel-based analysis of magnetisation
transfer ratio (MTR) demonstrates decreased MTR in the same grey matter regions but for the same threshold (p