Electronic Posters: Neuroimaging - ismrm

white matter showed significant and widespread alterations throughout the brain of ALS patients. In the gray matter of the ALS group,
significant differences were found in the left frontal- and left parietal lobes for NAA/Cr, and bilateral frontal lobe for Cho/NAA.
15:30 4261. Brain DT MRI Predicts the Long-Term Clinical Evolution in Amyotrophic Lateral
Sclerosis: A 3.4 Year Follow Up Study
Federica Agosta 1 , Elisabetta Pagani 1 , Melissa Petrolini 1 , Maria Pia Sormani 2 , Domenico
Caputo 3 , Michele Perini 4 , Alessandro Prelle 5 , Fabrizio Salvi 6 , Massimo Filippi 1
1 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific
Institute and University Hospital San Raffaele, Milan, Italy; 2 Unit of Biostatistics, DISSAL, University of
Genoa, Genoa, Italy; 3 Department of Neurology, Scientific Institute Fondazione Don Gnocchi, Milan, Italy;
4 Department of Neurology, Ospedale di Gallarate, Gallarate, Italy; 5 Dino Ferrari Center, Department of
Neuroscience, University of Milan, Milan, Italy; 6 Department of Neurology, Ospedale di Bellaria, University of
Bologna, Bologna, Italy
We investigated whether corticospinal tract (CST) DT-MRI changes contribute to the prediction of long-term clinical evolution in
patients with amyotrophic laterals sclerosis (ALS). Conventional and DT-MRI were obtained in 24 ALS patients, who were followed
prospectively for 3.4 years. Compared with controls, ALS patients showed increased MD and decreased FA of the CST. Shorter
disease duration and lower CST FA were associated with disability worsening. Bulbar-onset and CST FA were independent predictors
of time to death in ALS patients. More severe DT-MRI abnormalities in the CST predicted a poorer clinical outcome after a 3.4 year
follow up in ALS patients.
Tuesday 13:30-15:30 Computer 73
13:30 4262. Altered Functional Connectivity of the Motor Network in Multiple System Atrophy
Feng Feng 1 , Hui You 1 , Han Wang 2 , Fuling Zheng 1 , Chunling Meng 1 , Jue Wang 3 , Yufeng
Zang 3
1 Radiology, Peking Union Medical College Hospital, Beijing, China; 2 Neurology, Peking Union Medical
College Hospital, Beijing, China; 3 State Key Laboratory of Cognitive Neuroscience and Learning, Beijing
Normal University, Beijing, China
MSA is mainly a sporadic neurodegenerative disease. Besides abnormalities of nigrostriatal pathway, the typical pathological findings
were also described in primary motor and supplementary motor cortices. We hypothesize that there is associated disturbance of
functional connectivity of the motor cortex in MSA patients. To test the hypothesis, resting-state functional MRI was used to measure
the coherent spontaneous fluctuations in the blood oxygenation level¨Cdependent signal. Our results showed regional homogeneity
changes in left precentral gyrus, right precuneus, supramarginal gyrus and middle frontal gyrus, indicating functional connectivity
disturbance of motor-related circuits and left-sided predominance of primary motor cortex involvement.
14:00 4263. The Topographical Distribution of White Matter Damage in Parkinson’s Disease
and Progressive Supranuclear Palsy
Federica Agosta 1 , Sebastiano Galantucci 1 , T Stojkovic 2 , A. Tomic 2 , Igor Petrovic 2 , Giulia
Longoni 1 , Vladimir Kostic 2 , Massimo Filippi 1
1 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific
Institute and University Hospital San Raffaele, Milan, Italy; 2 Department of Neurology, School of Medicine,
University of Belgrade, Belgrade, Yugoslavia
Using TBSS, we investigated WM changes in 39 Parkinson’s disease (PD) patients, 20 progressive supranuclear palsy (PSP) patients
(10 Richardson’s syndrome [PSP-RS] and 10 PSP-Parkinsonism [PSP-P]), and 26 controls. PSP-RS showed the most pronounced
pattern of decreased FA, including both infratentorial and supratentorial regions, vs. controls and other patient groups. A similar
pattern of FA decrease (except for superior cerebellar peduncle) was found in PSP-P vs. controls and PD (only at a lower
significance). Impaired WM integrity was found in PSP but not in PD. The less prominent WM involvement in PSP-P might be
associated to its favorable clinical status.
14:30 4264. The In-Vivo Topographical Distribution of Brain Tissue Loss Associated with
Depression in Parkinson’s Disease: A Voxel-Based Morphometry Study
Massimo Filippi 1 , Federica Agosta 1 , Igor Petrovic 2 , Sebastiano Galantucci 1 , Vladana
Spica 2 , Milica Jecmenica 2 , Vladimir Kostic 2
1 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific
Institute and University Hospital San Raffaele, Milan, Italy; 2 Department of Neurology, School of Medicine,
University of Belgrade, Belgrade, Yugoslavia
VBM was used to investigate whether specific patterns of gray (GM) and white matter (WM) loss are associated with depression in 40
patients with Parkinson’s disease (PD). Twenty-four PD were diagnosed as non-depressed (PD-NDep), and 16 as having depression
(PD-Dep). Compared with PD-NDep, PD-NDep showed WM loss in the right anterior cingulum and inferior orbitofrontal (OF)
region. In PD patients, Hamilton rating scale for depression score correlated significantly with right inferior OF WM. The pattern of
brain atrophy in PD-Dep overlaps with the key regions involved in major depressive disorders, suggesting an increased vulnerability
of this neural circuit in PD.