Electronic Posters: Neuroimaging - ismrm

14:30 4364. Measurement of Iron Concentration in Human Brain Using Quantitative
Susceptibility Mapping (QSM): Correlation with Age
Tian Liu 1,2 , Jing Liu 2 , Ludovic de Rochefort 3 , James Ledoux 2 , Qing Zhang 4 , Martin R.
Prince 2 , Jianlin Wu 4 , Yi Wang 1
1 Biomedical Engineering, Cornell University, New York, NY, United States; 2 Radiology, Weill Cornell
Medical College, New York, NY, United States; 3 MIRCen, I2BM, DSV, CEA, Fontenay-aux-Roses, France;
4 Radiology, The 1st Hospital of Dalian Medical University, Dalian, Liaoning, China
Increasing iron deposition with increasing age has been confirmed in postmortem studies and observed in in vivo MRI. In this 100
volunteer study, we specifically measured susceptibility in putamen, and converted it to Fe3+ concentration. A strong linear
correlation was obtained between susceptibility and age. The iron concentration agreed well with postmortem results.
15:00 4365. Improved Inter-Subject Functional Registration Using DARTEL in Individuals
Prenatally Exposed to Alcohol
Priya Santhanam 1 , Zhihao Li 1 , Claire Coles 2 , Mary Ellen Lynch 2 , Xiaoping Hu 1
1 Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA,
United States; 2 Department of Psychiatry and Behavioral Sciences, Emory University
On account of multifaceted structural damage induced by prenatal alcohol exposure (PAE), MR image registration problems have
been a roadblock in the detailed analysis of images from this population. The present study examines the applicability of DARTEL
(diffeomorphic anatomical registration through exponentiated lie algebra) to functional image registration in the PAE population. As
compared to Talairach transformation, functional image registration by DARTEL had more group difference clusters in expected
regions, and significant correlation between intensity over one difference cluster and known exposure-related measures. Results imply
DARTEL may be a more accurate method for functional image registration for the PAE population.
Wednesday 13:30-15:30 Computer 79
13:30 4366. Do Differences in Myelin Underlie the The Schizotypal Personality Spectrum?
Katrina McMullen 1 , Shannon Kolind 1,2 , Emma Barkus 3 , Sean CL Deoni 1
1 Centre for Neuroimaging Sciences, Institute of Psychiatry, London, England, United Kingdom; 2 Centre for
Functional Magnetic Resonance Imaging of the Brain, Oxford University, Oxford, England, United Kingdom;
3 Department of Psychiatry, University of Wollongong, NSW, New South Wales, Australia
Alterations in region grey matter volume, white matter structure and brain function are known associates schizophrenia and
schizophrenia spectrum disorders. However, the underlying etiology of these disorders, believed to represent a spectrum of psychosis
proneness, remains unknown. Increasingly, the role of white matter connectivity, mediated by myelin, to these disorders is being
questioned. Here we report on a study of myelin content in schizotypy, revealing a linear association between schizotypy score and
myelin water fraction, localized to the left hemisphere. These results, consistent with prior fMRI results, are suggestive of altered
white matter efficiency and processing ability in high schizotypes.
14:00 4367. Clinical 1H MRS Studies of Glutamatergic Neurotransmission in Bipolar Disorder
Wen-Jang Chu 1,2 , Mathew Norris 3 , Renu Kotwal, Caleb M. Adler, Mi-Jung Kim, Rachel
Whitsel, Jing-Huei Lee, 23 , Melissa P. DelBello, Stephen M. Strakowski, 2
1 Psychiatry, Univ. of Cincinnati, Cincinnati, OH, United States; 2 Center for Imaging Research, Univ. of
Cincinnati, Cincinnati, OH, United States; 3 Biomedical Engineering, Univ. of Cincinnati
Glutamate (Glu) has been found play an important role in Bipolar Disorder (BD). The accurate measurement of Glu has been hurdled
by the large signals overlapping and broadening baseline. Instead of reporting Glu levels, the Glx (sum of glutamate, glutamine and
GABA) has been widely used in glutamatergic neurotransmission research. In this work, we studied Glu levels using short echo
PRESS spectroscopy, and TE-averaged spectroscopy in medication-free, lithium-treated BD patients and healthy volunteers. The
results have allowed us to evaluate the Glu level differences between the two groups, and the effect of lithium treatment on Glu levels.
14:30 4368. Impaired Brain Circuitry and High-Energy Phosphates in Bipolar Disorder
Wen-Jang Chu 1,2 , Amanda Stover 3 , Jonathan Dudley 4 , David Caldwell 2 , Amanda Marie
Opaskar 2 , Mathew Norris 4 , Martine Lamy 2,3 , Jane Allendorfer 2,3 , Stephen M.
Strakowski 1,2 , Jing-Huei Lee 2,4 , James C. Eliassen 1,2
1 Psychiatry, Univ. of Cincinnati, Cincinnati, OH, United States; 2 Center for Imaging Research, Univ. of
Cincinnati, Cincinnati, OH, United States; 3 Graduate Program in Neuroscience, Univ. of Cincinnati;
4 Biomedical Engineering, Univ. of Cincinnati
The combined approach of fMRI and 31P spectroscopy is used to investigate 1) abnormal brain activation, and 2) the correlation
between high-energy phosphates and abnormal activation in the brains of patients with bipolar disorder. A behavioral task, the Balloon
Analogue Risk Task, was used during fMRI to identify brain regions that differed between bipolar and healthy subjects. Several
regions within anterior limbic network such as amygdala, ventrolateral prefrontal cortex and orbitofrontal cortex were identified by
fMRI activation differences. 31P MRSI data showed significant alterations of Pi, PDE and PCr in some of these regions.