Electronic Posters: Neuroimaging - ismrm

14:30 4436. MR Velocity Mapping of 3D Cerebrospinal Fluid Flow in the Patients with
Enlarged Ventricular System: Preliminary Results
Andreas Stadlbauer 1 , Wilma van der Riet 2 , Erich Salomonowitz 1
1 MR Physics Group, Department of Radiology, Landesklinikum St. Poelten, St. Poelten, Austria; 2 European
MRI Consultancy (EMRIC), Strasbourg, France
To study the CSF-flow dynamics in nine patients with enlarged ventricular system and nine volunteers using time-resolved 3D MR
velocity mapping. Particle-path-lines were calculated to visualize CSF-flow patterns. From six patients with suspected hydrocephalus
internus, four showed a hypomotile and two showed a hypermotile CSF-flow. From two patients with suspected normal pressure
hydrocephalus, one showed hypomotile and the other hypermotile CSF-flow. One patient who had undergone a ventriculostomy 10
yrs ago showed normal CSF-flow dynamics. These preliminary findings indicated changes in CSF-flow dynamics in patients with
enlarged ventricular system, but further and more detailed studies are necessary.
15:00 4437. Variability in Growth Rates of Fusiform, Dysmorphic Intracranial Aneurysms as
Evaluated by CE-MRA
David Saloner 1,2 , Loic Boussel 3 , Vitaliy Rayz 1 , Alastair Martin 1 , Michael Lawton 4
1 Radiology, UCSF, San Francisco, CA, United States; 2 VA Medical Center, San Francisco, CA; 3 Radiology,
CREATIS-LRMN, Lyon, France; 4 Surgery, UCSF, San Francisco, CA, United States
Estimation of the stability of dysmorphic fusiform aneurysms of the intra-cranial internal carotid artery requires precise monitoring of
their volumes. We used MRA and 3D post-processing to study the evolution of these aneurysms on a prosepective cohort of patients
with fusiform aneurysms of the intra-cranial internal carotid artery who were studied over multiple time points. The study found that
MRA is an excellent method to monitor growth and that 3D quantitative volumetric methods should be employed to monitor whether
any growth has occurred. In dysmorphic, fusiform aneurysms of the anterior circulation growth rate was very slow supporting
“watchful waiting”.
High Resolution Brain Imaging
Hall B Monday 14:00-16:00 Computer 84
14:00 4438. Increased Detectability of Alzheimer Plaques at 7T Vs. 3T Using High Resolution
BSSFP
Michael Zeineh 1 , Hagen Kitzler 2 , Scott Atlas 1 , Brian Rutt 1
1 Radiology, Stanford University Medical Center, Stanford, CA, United States; 2 Neuroradiology, Technische
Universitaet Dresden, Dresden, Germany
Beta amyloid plaques may have a significant role in the development of Alzheimer’s disease. MRI has been used to visualize these
plaques in humans ex vivo, but the etiology of the signal changes associated with plaques is unclear. We imaged 5 human AD
specimens and 5 normal specimens at 3.0T and 7.0T with a 3.5 hour bSSFP sequence tailored to visualize plaques. While image SNR
was approximately 1.7 times higher at high field, presumed plaque CNR was three times higher. This nonlinear increase may be
explained by a field-sensitive microscopic component of amyloid plaques.
14:30 4439. Reliable Amygdala Segmentation Using Clustering of Multimodal Data at 7 Tesla.
Eugenia Solano-Castiella 1 , Gabriele Lohmann 1 , Andreas Schäfer 1 , Robert Trampel 1 ,
Robert Turner 1
1 Neurophysics, Max Planck Institute, Leipzig, Sachsen, Germany
The amygdala is a relatively small brain structure. Its location next to the sphenoidal sinus results in a variety of MR image artifacts,
which increase with field strength. However, brain scanning at 7T provides considerable improvement of SNR and CNR having the
potential for in vivo parcellation of amygdala images into neurologically significant subdivisions that may improve interpretation of
fMRI-based neuropsychological studies. To improve clustering we used the strategy of combining images (GRE and TSE) having
different contrast mechanisms. The analysis and clustering techniques we have developed for this purpose may assist parcellation of
other deep brain structures.
15:00 4440. Segmentation of the Frontal Lobe Using Inversion Recovery Cortical Layers
Imaging
Daniel Barazany 1 , Ory Levy 1 , Yaniv Assaf 1
1 Neurobiology, Tel Aviv University, Tel Aviv, Israel
Inversion recovery (IR) MRI provides a unique contrast that enables segmentation of the cortex in a laminar way. In this work we
used multi IR images to cluster the frontal lobe into 5 distinct laminar sub-cortical structures. We found that each cluster has its own
relaxation curve. Statistical analysis on the composition of 6 Brodmann's areas (BA) along the frontal lobe has shown that there is an
interaction between different BAs and the MRI clusters. To validate our methodology, we were capable to identify the stripe of
Gennari at BA17 in the visual cortex using this framework.